ID   MUTL_LACLM              Reviewed;         656 AA.
AC   A2RP08;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=llmg_2489;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AM406671; CAL99053.1; -; Genomic_DNA.
DR   RefSeq; WP_011836118.1; NC_009004.1.
DR   AlphaFoldDB; A2RP08; -.
DR   SMR; A2RP08; -.
DR   STRING; 416870.llmg_2489; -.
DR   EnsemblBacteria; CAL99053; CAL99053; llmg_2489.
DR   KEGG; llm:llmg_2489; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; A2RP08; -.
DR   BioCyc; LLAC416870:LLMG_RS12505-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..656
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010034"
FT   REGION          385..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   656 AA;  73798 MW;  E796FE5966D0B0ED CRC64;
     MGKIIELNEA LANQIAAGEV VERPASVVKE LVENSIDAGS SKIIINVEEA GLRLIEVIDN
     GLGLEKEDVA LALRRHATSK IKDSADLFRI RTLGFRGEAL PSIASVSQMT IETSNAQEEA
     GTKLIAKGGT IETLEPLAKR LGTKISVANL FYNTPARLKY IKSLQAELSH ITDIINRLSL
     AHPEISFTLV NEGKEFLKTA GNGDLRQVIA AIYGIGTAKK MREINGSDLD FELTGYVSLP
     ELTRANRNYI TILINGRFIK NFLLNRAILE GYGNRLMVGR FPFAVLSIKI DPKLADVNVH
     PTKQEVRLSK ERELMTLISK AIDETLSEGV LIPEALENLQ GRAKEKGTVS VQTELPLQNN
     PLYYDNVRQD FFVREEAIFE INKNDNSDSL TEQNSTDYTV NQPETGSVSE KITDRTVESS
     NEFTDRTPKN SVSNFGVDFD NIEKLSQQST FPQLEYLAQL HATYLLCQSK EGLYLVDQHA
     AQERIKYEYW KDKIGEVSME QQILLAPYLF TLPKNDFIVL AEKKDLLHEA GVFLEEYGEN
     QFILREHPIW LKETEIEKSI NEMIDIILSS KEFSLKKYRH DLAAMVACKS SIKANHPLDA
     ESARALLREL STCKNPYSCA HGRPTIVHFS GDDIQKMFRR IQETHRSKAA SWKDFE