ID   MUTL_LACP3              Reviewed;         651 AA.
AC   Q035Z3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LSEI_2234;
OS   Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 /
OS   CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=321967;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL
RC   B-441;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000423; ABJ70979.1; -; Genomic_DNA.
DR   RefSeq; WP_003567013.1; NC_008526.1.
DR   RefSeq; YP_807421.1; NC_008526.1.
DR   AlphaFoldDB; Q035Z3; -.
DR   SMR; Q035Z3; -.
DR   STRING; 321967.LSEI_2234; -.
DR   EnsemblBacteria; ABJ70979; ABJ70979; LSEI_2234.
DR   GeneID; 61270357; -.
DR   KEGG; lca:LSEI_2234; -.
DR   PATRIC; fig|321967.11.peg.2196; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001651; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..651
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010029"
FT   REGION          383..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  72110 MW;  D032ECCACF75BE3F CRC64;
     MPKIHQLSAT LSNQIAAGEV IERPASVVKE LVENSIDAQA TQIDVLISAA GLQEIRVSDN
     GIGIAPDDVA TAFLRHATSK ILTTRDLFNV HSLGFRGEAL ASIAAVADVK LTTATDSGIG
     TQIHVKGGEV EAQSTAAHRR GTDVEVNDLF FNTPARLKYM KSQQTELGKI VDIVSRLAMA
     NPDIAFTVSH DGNMVVRTAG QGDLRQTLAG IYGLSVARSM VDFKAQDLDF RVSGLTSLPE
     TTRASRNYLS LVVNGRYIKN FQLTKAVIAG YGSKLMVGRY PMGVINIEMD AALVDVNVHP
     TKAEVRLSKE DQLSHLLSEA IRTRLAKENL IPDALDNLPK RERYDLDQLE LTLNKISPKT
     MPSVQPQQGQ QLRENTTTNL ADTAAEEPTP APTSPDLEIG DLDDQPIFNE PQRLAAWDQR
     YQRLASNVVP TLVADEPEPD ISHVESAERF PNLTYLAQVH GTYLLAESGD GLYILDQHAA
     QERVNYEYYR QAIGEVSNDQ QHLLVPIVLD YSAADAISIR DHRDVLESVG LYLEDFGQNS
     FVVEHHPTWF KAGQEEDTIK EMVDWVLRDG RMTVAAFREK TAIMMSCKRA IKANHHLDDR
     QARALLQKLP ECENPFNCPH GRPVLVHFSN TDLEKMFKRI QDSHESGEMQ A