ID   MUTL_LACPL              Reviewed;         678 AA.
AC   Q88UZ8; F9UQK8;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; Synonyms=hexB;
GN   OrderedLocusNames=lp_2297;
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL935263; CCC79497.1; -; Genomic_DNA.
DR   RefSeq; WP_011101707.1; NC_004567.2.
DR   RefSeq; YP_004890011.1; NC_004567.2.
DR   AlphaFoldDB; Q88UZ8; -.
DR   SMR; Q88UZ8; -.
DR   STRING; 220668.lp_2297; -.
DR   EnsemblBacteria; CCC79497; CCC79497; lp_2297.
DR   GeneID; 57025833; -.
DR   KEGG; lpl:lp_2297; -.
DR   PATRIC; fig|220668.9.peg.1941; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; Q88UZ8; -.
DR   BioCyc; LPLA220668:G1GW0-1981-MON; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..678
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177949"
SQ   SEQUENCE   678 AA;  74105 MW;  00716FCF9969690F CRC64;
     MGKIHELSSV LADQIAAGEV VERPASVVKE LVENAVDAHA TQVDILVQES GVQSIRVIDD
     GDGIDDAEVL TAFKRHATSK ITSREDLFRV HSLGFRGEAL PSIASVADVV MNTSTGATGT
     SIHYRGGKLL QQSPAPLRQG TDITVTDLFF NTPARLKYLK SPQTELANIL DVVNRIALSY
     PAVAFRLVHN AKELLKTAGR GDLQQVIAGI YGVQNARKMV AIQGSTTDFK LSGFVALPEL
     TRASRQYITV LINGRAIKNQ QLTKAVIKGY GSKLMVGRYP IAVIALTMDP LLVDVNVHPT
     KQEVRLSKEP ELAKLVSTTI TDRLVDVNLI PSALTNLGSH RREHLNTDQL AMDLNAVSSQ
     YQVADKTTPA STEQFAASLA AATMQPSSAT TMVSTTSAQP SAVNRAAVSA VVPSESAASS
     ANQPIMISHR DELTATPVQA FDQRYQSESG ALPFGETAEP LETSTAASAP TSEAPDTERF
     PQLRYLGQMH GTYLLAEADD GMYILDQHAA QERINYEYYR QAIGEVSADQ QNLLVPIILD
     YPTSDVLKIK EKLPLLAELG IHLESFGGNS FIVHAHPTWF KAGQEEDTIR EMIDWLLQDD
     KLTVAQFREK SAIMMSCKRA IKANHHLDDQ QARALLAKLP TCENPFNCPH GRPVTVHFTN
     SDMERMFKRI QDSHEARD