ID   MUTL_LEPBA              Reviewed;         614 AA.
AC   B0SB85;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LBF_2096;
OS   Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=355278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Patoc 1 / Ames;
RX   PubMed=18270594; DOI=10.1371/journal.pone.0001607;
RA   Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N.,
RA   Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A.,
RA   Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L.,
RA   Rood J.I., Lajus A., Davies J.K., Medigue C., Adler B.;
RT   "Genome sequence of the saprophyte Leptospira biflexa provides insights
RT   into the evolution of Leptospira and the pathogenesis of leptospirosis.";
RL   PLoS ONE 3:E1607-E1607(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000777; ABZ94591.1; -; Genomic_DNA.
DR   RefSeq; WP_012389123.1; NC_010842.1.
DR   AlphaFoldDB; B0SB85; -.
DR   SMR; B0SB85; -.
DR   PRIDE; B0SB85; -.
DR   KEGG; lbf:LBF_2096; -.
DR   HOGENOM; CLU_004131_4_1_12; -.
DR   OMA; AHERIMY; -.
DR   BioCyc; LBIF355278:LBF_RS10620-MON; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..614
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096662"
SQ   SEQUENCE   614 AA;  69049 MW;  64C7218462C48604 CRC64;
     MGIIHSLSPD LINQIAAGEV IESTHSILKE LIENSIDAGA SKIEIATESA GLGRILVSDD
     GHGITKEDLP LAIKRYATSK IQTFHDLEHL FTFGFRGEAL ASIASVSRLV IESGTEGNRM
     AQRVVVEEGK VVSEEEIPFF QGTKIEIKDL FYNTPVRRKF LKTESGEEKK NRTRVQTMAL
     GEPSIGFRYV QNGKEVFHVQ KEEPLERVLS IYGENLRDHL LPVHSSRNGM TLRGFISHPD
     FYKSSRMGQF FFVNNRSVEL KFSAQILKRC YGELLPSGAF PYAFLFFDLP REFVDVNVHP
     QKKEVRFLSE ETITGILFQG ITEVLRTSTP VEFLEMRRRL SMPIPYHSSA DKSQFGGEGM
     SMGGPGFGFG MAGRGQAVWG SQNEEGNPLL GPSSIEGRAG FSLDGIGAGT NLHLLGDNLT
     KHNLFVPKKH YGVIFETFIL AEAEDGLYII DQHTAHERIR YEEVLRDLKS KAYKSQSLLT
     PIRLELTKEE AEEMIAEKHR FSELGITLEP FSGGTILIRE VPSYIDPGKE TETILDLWER
     FKSKDPEEKE LYDEMAKCVA CRSAIKKGDQ VSDPIIGELL QRLSYCENPS LCPHGRPTLI
     KLTRKDLETM FHRI