ID   MUTL_LEPBJ              Reviewed;         596 AA.
AC   Q04QW2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LBJ_2225;
OS   Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=355277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JB197;
RX   PubMed=16973745; DOI=10.1073/pnas.0603979103;
RA   Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A.,
RA   Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L.,
RA   Rood J.I., Davies J.K., Adler B.;
RT   "Genome reduction in Leptospira borgpetersenii reflects limited
RT   transmission potential.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000350; ABJ76708.1; -; Genomic_DNA.
DR   RefSeq; WP_011671940.1; NC_008510.1.
DR   AlphaFoldDB; Q04QW2; -.
DR   SMR; Q04QW2; -.
DR   EnsemblBacteria; ABJ76708; ABJ76708; LBJ_2225.
DR   KEGG; lbj:LBJ_2225; -.
DR   HOGENOM; CLU_004131_4_2_12; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000656; Chromosome 1.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..596
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010037"
SQ   SEQUENCE   596 AA;  67702 MW;  5DFC905BF9BCD94B CRC64;
     MGKIQELSPE LINQIAAGEV IESAHSVVKE LMENSMDAGA TQMDIESKDG GLSLLRITDN
     GSGIDPEDIE PALKRHATSK IRDYGDLENV LSYGFRGEAL ASIASVSRLT LESGIKNQKT
     AWKICSIGGK ISEKEEIPGF VGTKILVEEL FFNTPVRRKF LKSVRSEDKK IRDRVTTQAL
     ARHDVRFRLF QDGKEVFVLP SRENKKDRIV DLFGENFRDH LLEVSLERGG LNATGYISDP
     DFYKSNRTGQ FVFVNGRPVE IKYGSTLLKK AYDELLPPNG HPYCFLFFEI DPSRVDVNVH
     PAKKEIRFLD EEGFNGFFLT LIQKELRSST PVSFLELKKR LLRPTPETFK TSSLYQAHSS
     SRSGESPLLS RELFTEVPRQ EGFDLDRMGP GASLSALTDN VVKHSSFVPK KHFGVLFETF
     ILAEAEDGFC IIDQHTAHER IRYEEVLRKL EKKNYGIQPL LTPIRIDVSK QEQEDILNRK
     KEYEEVGIFL DPLGEDSVVL REIPAYMEPG EEKEIILDFL NRTEGKETTE PELYDLMAKC
     VACRSAIKKG DHLSDPILAE ILNRLSYCEN PSRCPHGRPT LVKLSRDDLE RMFHRK