ID   MUTL_LEPIN              Reviewed;         593 AA.
AC   Q8F6X4;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LA_1175;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010300; AAN48374.2; -; Genomic_DNA.
DR   RefSeq; NP_711356.2; NC_004342.2.
DR   RefSeq; WP_000516444.1; NC_004342.2.
DR   AlphaFoldDB; Q8F6X4; -.
DR   SMR; Q8F6X4; -.
DR   STRING; 189518.LA_1175; -.
DR   EnsemblBacteria; AAN48374; AAN48374; LA_1175.
DR   GeneID; 61142391; -.
DR   KEGG; lil:LA_1175; -.
DR   PATRIC; fig|189518.3.peg.1170; -.
DR   HOGENOM; CLU_004131_4_1_12; -.
DR   InParanoid; Q8F6X4; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..593
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177951"
SQ   SEQUENCE   593 AA;  67640 MW;  FA5D1FA015067D34 CRC64;
     MGKIQELSPE LINQIAAGEV IESAHSVVKE LMENSMDASA TQVDVESKDG GLSLLRITDN
     GTGIEPEDLE PALKRHATSK IQDYKDLESV LSYGFRGEAL ASIASVSRLT LESGTKEQKT
     AWKTRSVAGK ISEKEEIPGF IGTKILVEEL FFNTPVRRKF LKSIRSEDKK IRDRVTTQAL
     AREDVRFRLF QDGKEVFVLP TRENKKERII DLFGENFRDH LLEVSLERGG IQATGYISDP
     DFYKSNRTGQ FIFINGRPIE IKYSSVLLKK AYDELLPPNG HPYCFLFFEI DPSRVDVNVH
     PAKREIRFLD EDGFNGFFLA LIQKELRSST PVSFLELKKR LLKPAPETHS TTSFYQARSS
     GKNPLLGREL FSGVSKQEGF ELDRMGPGVS LSELTDERVK HSSFVPKKHF GVLFETFILA
     EAEDGFYIID QHTAHERIRY EEVLRKLEKR NYGIQPLLTP IRIDVSKQEQ EDILNRKKEY
     EEVGIFLDPL GEDSIVLREI PAYMEPGQEK EIVLDFLNRT EGKETSEPEL YDLMAKCVAC
     RSAIKKGDQL SDPILAEILN RLSYCENPSR CPHGRPTLVK LSRDDLERMF HRK