ID   MUTL_LEUCK              Reviewed;         668 AA.
AC   B1N024;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LCK_01302;
OS   Leuconostoc citreum (strain KM20).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Leuconostoc.
OX   NCBI_TaxID=349519;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KM20;
RX   PubMed=18281406; DOI=10.1128/jb.01862-07;
RA   Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S.,
RA   Lee S., Park H.-S., Park Y.-H., Oh T.K.;
RT   "Complete genome sequence of Leuconostoc citreum KM20.";
RL   J. Bacteriol. 190:3093-3094(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; DQ489736; ACA83126.1; -; Genomic_DNA.
DR   RefSeq; WP_004909029.1; NC_010471.1.
DR   AlphaFoldDB; B1N024; -.
DR   SMR; B1N024; -.
DR   STRING; 349519.LCK_01302; -.
DR   EnsemblBacteria; ACA83126; ACA83126; LCK_01302.
DR   KEGG; lci:LCK_01302; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002166; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..668
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096664"
FT   REGION          437..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   668 AA;  74932 MW;  4434A73B9195785A CRC64;
     MGKIHELSNL LANQIAAGEV IERPASVVKE LVENAIDAGA TQIDIVVENA GETFIRVVDN
     GAGIDPVDVP LAFTRHATSK ITDRHDLFNI VSLGFRGEAL PSIAAIADVE LRTKTTETTT
     GLNYHIKGGK EISATPANGR RGTVITVRDL FYNTPARLKY LKKHQTELSK IVDIINRLAL
     SYTGIAFTVS ADGRSLLRTT GNGNQQQVIA GIYGRDNAQK MLAIAGENDD FNITGFISLP
     ELTRGSREYL TVLVNGRYIK NFAVSNAVIR GYGSKLMVGR FPMGVININT NPLLIDVNVH
     PQKSEIRLSK ETELAELLVT TIKNRLAEEN LIPDAYETLY GQQNKQQNTQ NTQNTFTPKA
     PWIAAEDSMD GHNAEKMSSQ PIRRSPSLVT PVEITKREEL SSDRVLTFTQ KYTNELPQPV
     FETDNVVEQQ VTEPTVTYQS QYSETGSHSQ ETLPLSEQKP TGFPALDYIG QMHGTFLFAQ
     SEDSFFLIDQ HAAQERVNYE FYREQIGQVT NDQQRLLVPI TIDYSVSEML AIADHQPELM
     ALGLRLEPFG ATTMIIREHP TWFEKGQEEE TVREMTDWLL RDGQLTVAQF REKAAIMMSC
     KRAIRANMHL SDTAARQLLA HLSMAENPYN CPHGRPVLTQ FTLTEMEKMF KRIQESHEKW
     ESYDNHPF