ID   MUTL_LIGS1              Reviewed;         659 AA.
AC   Q1WT16;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LSL_1127;
OS   Ligilactobacillus salivarius (strain UCC118) (Lactobacillus salivarius).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Ligilactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCC118;
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K.,
RA   Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000233; ABD99935.1; -; Genomic_DNA.
DR   RefSeq; WP_011476177.1; NC_007929.1.
DR   RefSeq; YP_536018.1; NC_007929.1.
DR   AlphaFoldDB; Q1WT16; -.
DR   SMR; Q1WT16; -.
DR   STRING; 362948.LSL_1127; -.
DR   PRIDE; Q1WT16; -.
DR   EnsemblBacteria; ABD99935; ABD99935; LSL_1127.
DR   KEGG; lsl:LSL_1127; -.
DR   PATRIC; fig|362948.14.peg.1200; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000006559; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..659
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010036"
SQ   SEQUENCE   659 AA;  74541 MW;  79E22B880B0AFE2F CRC64;
     MAKIHELSEI LANQIAAGEV VERPASVVKE LVENSIDAGA KQIDIIIEDA GLKSIQIIDD
     GNGIEAEDVE TAFKRHATSK IIDRKDLFKV HTLGFRGEAL PSIASVSDVV METAVSGRAG
     TKIHIKGGEV LEKTLSASRE GTTITVSDLF YNTPARLKYL KSVQTELSYI SDIVNRLALS
     HTDVALSLTN NGRQLLQSAG NGNLQQTIGA IYGVQNARQM IKFEDANLDF KISGYTSLPK
     LTRASRNYIS LLVNGRYVKN FQLTKAVIEG YGSKLMTGRY PITVLSIELD PTLVDVNVHP
     TKQEIKISKE DELVTFIQKT IFERIGQENL IPDGLQNIKS KTKEKLDFEQ LKVGLNEASK
     QYQTKQHRTG ITSEVTAALF GEKLTKDESQ TQTNEKIKEE TKVELSPIII KDKQDLKSDR
     VKEWDEKYQS RNKETEVTSI AEKNGSVDDK RKDTPRFPTL RYIGQMHGTF LFAEGEEGLY
     IVDQHAAQER VKYEYYREEI GKVSPTQQNL LVPIVLTYPT TDALIIDENI DKLKELGIYL
     EDFGQNTYII RQHPTWFKEG QEESIIREMI DYFLKDRKLS IAKFREKTAI MMSCKRSIKA
     NHHLDDKQAK SILEQLKTCE NPFNCPHGRP VLVKLSNKDL EHMFKRIQDP HHTGILEED