ID   MUTL_LIMF3              Reviewed;         647 AA.
AC   B2GB18;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LAF_0514;
OS   Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251) (Lactobacillus
OS   fermentum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=334390;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 3956 / LMG 18251;
RX   PubMed=18487258; DOI=10.1093/dnares/dsn009;
RA   Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T.,
RA   Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T.,
RA   Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T.,
RA   Hattori M.;
RT   "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus
RT   fermentum reveal a genomic island for reuterin and cobalamin production.";
RL   DNA Res. 15:151-161(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP008937; BAG26850.1; -; Genomic_DNA.
DR   RefSeq; WP_003682813.1; NC_010610.1.
DR   AlphaFoldDB; B2GB18; -.
DR   SMR; B2GB18; -.
DR   EnsemblBacteria; BAG26850; BAG26850; LAF_0514.
DR   GeneID; 61200437; -.
DR   KEGG; lfe:LAF_0514; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001697; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..647
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096660"
FT   REGION          346..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   647 AA;  71186 MW;  75F2252683474D73 CRC64;
     MGKIHELDSV LADQIAAGEV IERPASIVKE LAENSLDANS HRIDIIVEEA GLKSVRVIDD
     GQGIEADDVA RAFLRHATSK IADKGDLFKV TTMGFRGEAL PSIASVADVL LTTATGGAAG
     SQIHIKGGEI LAHGQASARP GTDILVSDLF YNTPARLKYL KSPHTELARI VDIVNRLALA
     NPTVAFSLTH DGKEVFRSAG NGNLKQVVAA IYGVQAGRKM VEVKGEDPNF KVSGLVSLPE
     LTRAGRQYMT IMINHRYVRN FQLTKALVAG YRSKLMVGRY PLAVINIDLD PVLVDVNVHP
     AKREVRLSME PQLVDLLERV VSQAIDQQNL IPDVGDRADE LLTREQTVHA PRSAAPRVSE
     RASDEPPAWQ PSPTSGEPVI ISRRSELASP AVQAFDRRYQ NEEVATPFGA QADAKVSQAQ
     PAVEQVSLDI DDRGDVASER FPDLTYLGQL HGTYLLAQAS DGLYIVDQHA AQERINYEYY
     REEIGKVSAD QQNFLTPLVL NYSLADALKI QQHQAVLAAC GLKLEPFGQN SFMLASHPTW
     FVAGQEEDTA REMIDWVLAS GKLSVKDFRA KAAIMMSCKR AIKANHRLDE RQAKALLARL
     PQCENPFNCP HGRPVTIHFT TTDLEKLFKR IQESHQPFAD DFDDHED