ID   MUTL_LIMRJ              Reviewed;         668 AA.
AC   B2G6E6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LAR_0512;
OS   Limosilactobacillus reuteri (strain JCM 1112) (Lactobacillus reuteri).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=557433;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 1112;
RX   PubMed=18487258; DOI=10.1093/dnares/dsn009;
RA   Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T.,
RA   Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T.,
RA   Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T.,
RA   Hattori M.;
RT   "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus
RT   fermentum reveal a genomic island for reuterin and cobalamin production.";
RL   DNA Res. 15:151-161(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP007281; BAG25028.1; -; Genomic_DNA.
DR   RefSeq; WP_003667624.1; NC_010609.1.
DR   AlphaFoldDB; B2G6E6; -.
DR   SMR; B2G6E6; -.
DR   GeneID; 66470646; -.
DR   KEGG; lrf:LAR_0512; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..668
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096661"
SQ   SEQUENCE   668 AA;  74807 MW;  7A5E9ECF8D3566DC CRC64;
     MGKIHELDNI LANQIAAGEV IERPASIVKE LVENSLDAHS HRVDIIVENS GLDSVRVIDD
     GDGIAAEDIS LAFHRHATSK INSRHDLFKV QTMGFRGEAL PSIASVADVT LTTAQAGQEE
     GTMIHLRGGK ELVVKPAGAR QGTDIKVTDL FFNTPARLKY LKSPQTELTR ITDIINRLAL
     ANPAVAFSFT HNGRELFRSA GNNNLQQVVA AIYGVQAGRK MLEISGADDD FKVSGFVSLP
     ELTRASRQYI TITINHRYIR NFELTKAIIQ GYESKLMVGR YPIAVINIDL DPVLVDVNVH
     PAKREVRLSK EQQLIKLIAE TIRQRIAVEN LIPDVDADQF IPNDDEVADL DRRLKEASPV
     YHAAPISAVP ATEKAATEIP TPEADNPAHA DALDSEIPAP IVIHHLEDLN TPAMQKFDER
     YQNEGEVTPF SAPVPTMTKK PVKPANIELD VHDKQDQQQN RFPDLQYIGQ LQGTFLLAQA
     GDGLYIVDQH AAQERINYEY YRQKIGEVSA DQQNFLVPLV LNYSTVDAMT INQHLDTLAA
     VGLELESFGQ NSFILRSHPT WFKEGQEEDT AEEMIDWLIK NGKLTVKEFR MKTAIMMSCK
     RAIKANHHLD EREAKALLKR LPQCENPFNC PHGRPVTVHF NDQDLEKMFK RIQDSHTPYA
     DDFDDHEF