ID   MUTL_LISMO              Reviewed;         601 AA.
AC   Q8Y788;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=lmo1404;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AL591979; CAC99482.1; -; Genomic_DNA.
DR   PIR; AD1250; AD1250.
DR   RefSeq; NP_464929.1; NC_003210.1.
DR   RefSeq; WP_003732291.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q8Y788; -.
DR   SMR; Q8Y788; -.
DR   STRING; 169963.lmo1404; -.
DR   PaxDb; Q8Y788; -.
DR   DNASU; 986410; -.
DR   EnsemblBacteria; CAC99482; CAC99482; CAC99482.
DR   GeneID; 986410; -.
DR   KEGG; lmo:lmo1404; -.
DR   PATRIC; fig|169963.11.peg.1443; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; Q8Y788; -.
DR   BioCyc; LMON169963:LMO1404-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..601
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177954"
SQ   SEQUENCE   601 AA;  67795 MW;  C80D6BABB8757EC9 CRC64;
     MAKHIVELTD ALSNKIAAGE VVERPASVVK ELVENAIDAG STVIDILVEE AGLNKITIID
     NGSGIEEEDV ATAFLRHATS KIKNEADLFR VHTLGFRGEA LPSIASVSHL AMETSTGETK
     GTSISLEGGK IIEQKSGHAR KGTQIEVSQL FFNTPARLKY LKSLPTELGN ITDILNRLAL
     AHPDISFRFS HNGKPLLQTN GNGDLRQVIA AIYGISIAKK SIPVKAESLD FKISGYAVLP
     EVNRSNRNYI STIINGRFIK NFALVKAIQE GYHTLLPIGR FPIIVLQIEM DPIIVDVNVH
     PAKLEVRLSK EKELGQLISQ MIKEAFHKLQ LIPEGEISKK QKEVQKSEQI QMSFEENKPA
     KEIPTLFSKP TIPEYVPSDE DAPREDDFIL ETMPPYEPQA EQEEHSKERI PKMYPIGQMH
     ATYIFAQNEN GLYIIDQHAA QERIKYEFYR EKIGEVSREL QELLVPIVLE FPADEYVRLE
     EQKAKLEEVG VFLENFGQNS FIIRAHPTWF PKDQEEEMLR EIIDEALSAP SISIHKLRED
     TAIMMSCKKS IKANHYLTTQ DMEALLDTLR EASDPFTCPH GRPVIIQYST YELEKMFKRV
     M