ID   MUTL_MACCJ              Reviewed;         633 AA.
AC   B9EBI5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=MCCL_0889;
OS   Macrococcus caseolyticus (strain JCSC5402).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Macrococcus.
OX   NCBI_TaxID=458233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC5402;
RX   PubMed=19074389; DOI=10.1128/jb.01058-08;
RA   Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.;
RT   "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402,
RT   reflecting the ancestral genome of the human-pathogenic staphylococci.";
RL   J. Bacteriol. 191:1180-1190(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP009484; BAH17596.1; -; Genomic_DNA.
DR   RefSeq; WP_012656796.1; NC_011999.1.
DR   AlphaFoldDB; B9EBI5; -.
DR   SMR; B9EBI5; -.
DR   STRING; 458233.MCCL_0889; -.
DR   EnsemblBacteria; BAH17596; BAH17596; MCCL_0889.
DR   KEGG; mcl:MCCL_0889; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001383; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..633
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000123211"
SQ   SEQUENCE   633 AA;  72295 MW;  0F7DA18348A32A5D CRC64;
     MGIIKTLDST ISNKIAAGEV IERPQSVVKE LVENAIDAKS TSITIEVEEA GLSKIKVTDN
     GSGILEEDLE LMFRRHATSK IENEHDLFHI RSLGFRGEAL ASIASVSKVR VTTCHDGSIG
     RQIDVIDGET VNRTLAQARQ GTEITVESLF YNTPARLKYV KSLHTELGKI TDIINRFVIS
     FPYIKFTLVA DGRVLIASNG NGKMQEAMAV VYGMKIAQDL VEVNGRTGDY EVHGFIAKPE
     HTRSNRHYMS LFINGRYIKN FMLTKAILSG YHTLLPVGRY PILAINIVMD PALVDVNVHP
     TKQEVRLSKE SQLMELIERL IKEKIWKQNL IPKVEKKKVL ETFQQQKFEY DLLREHRDKT
     KQSDYSEQTA VNQIDEKFKE QHKTAQLDKQ RVPDGESTQK TTGFISDSAA ELDTTSEILP
     EKNESSDVIE NISTDTSREK RKIPYMEIVG QVHGTYIIAQ NEDGMFMIDQ HAAQERIKYE
     YFKKQIGDVG LEMQSLLIPI TVTLSKDEAI NLNKINILLK DIGIHLEHFG GNDYIINDIP
     VWFPDNYEET VQELIDYALQ HRQIDLNKFR EETAIMMSCK KSIKANHYLR ITDMNYLLEE
     LAHTVEPYTC PHGRPIIIQF TTYELEKLFK RVM