ID   MUTL_MAGSA              Reviewed;         607 AA.
AC   Q2VYV5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=amb4416;
OS   Magnetospirillum magneticum (strain AMB-1 / ATCC 700264).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Magnetospirillum.
OX   NCBI_TaxID=342108;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AMB-1 / ATCC 700264;
RX   PubMed=16303747; DOI=10.1093/dnares/dsi002;
RA   Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.;
RT   "Complete genome sequence of the facultative anaerobic magnetotactic
RT   bacterium Magnetospirillum sp. strain AMB-1.";
RL   DNA Res. 12:157-166(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP007255; BAE53220.1; -; Genomic_DNA.
DR   RefSeq; WP_011386761.1; NC_007626.1.
DR   AlphaFoldDB; Q2VYV5; -.
DR   SMR; Q2VYV5; -.
DR   STRING; 342108.amb4416; -.
DR   EnsemblBacteria; BAE53220; BAE53220; amb4416.
DR   KEGG; mag:amb4416; -.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000007058; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..607
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010040"
SQ   SEQUENCE   607 AA;  63967 MW;  A05C3C4F3F6E63D5 CRC64;
     MSIRLLPPTL VNQIAAGEVV ERPASAVKEL VENAIDAGAS RIDVVLAEGG QSLIAVSDDG
     CGMSPDEMML AVERHATSKL PDDDLVRIRF LGFRGEALPS IGSVARLTLT SRPRGADSAW
     SLSVEGGAKG RPVPAAHPQG TRIEVRDLFY ATPARLKFLK AARTELTHAA DVIERLGMAH
     PDIAFSLSDG GRKVLDLAAK RGEPGAALLS RIAQVVGREF EPNALALDAE RDGVRLTGWA
     GLPTYNRATS AAQYLFVNGR PVKDRLVIGA VRGAYQDVLA RDRHPVVALF LELDPDQVDV
     NVHPAKAEVR FRDSGLVRGL IVGAIRHALA GAGHRASSTL TGVALGALGG GGGNSPPPSF
     AHYPPPRPSL PLIRAGIGAQ APLGLAEQGL GLHLPPAAPV APPEAREGPG EASVDYPLGA
     AKAQLHDTYI VAETADGLVI VDQHAAHERL VFERLKLGLT EGQVARQGLL LPEVVDLGDA
     GAARVTERAG DLARLGLVID SFGPGAVVVR EVPALLGDDD VQGLVRDLAD ELAEWGASTV
     LEERLLHICA TMACHGSVRA GRRLSVPEMN ALLRRMEATP LSGQCNHGRP THVSLSLNDI
     EKLFGRR