ID   MUTL_MANSM              Reviewed;         631 AA.
AC   Q65SD7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=MS1516;
OS   Mannheimia succiniciproducens (strain MBEL55E).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBEL55E;
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA   Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE016827; AAU38123.1; -; Genomic_DNA.
DR   RefSeq; WP_011200689.1; NC_006300.1.
DR   AlphaFoldDB; Q65SD7; -.
DR   SMR; Q65SD7; -.
DR   STRING; 221988.MS1516; -.
DR   EnsemblBacteria; AAU38123; AAU38123; MS1516.
DR   KEGG; msu:MS1516; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; WKHDDLH; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..631
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010041"
SQ   SEQUENCE   631 AA;  70906 MW;  D009C3A26B8235A8 CRC64;
     MPIHILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAS RIQIDIENGG ATLIRIRDNG
     LGIAKEDLSL ALARHATSKI SCLDDLEAIL SLGFRGEALA SISSVSRLTL TSRTAEQKEA
     WQVYAQGRDM ETTIKPASHP VGTTVEVANL FFNTPARRKF LRTEKTEFAH IDEVVRRIAL
     AKPQIAFTLT HNGKILRQYK SAVEIEQKLK RVSAICGEDF VQNALQIDWK HDNLHLSGWV
     AVPNFHRPQN DLSYSYVNGR MIRDKVINHA IRQAYGDYLT NEQYPAFVLY LDLDPNEVDV
     NVHPTKHEVR FHQARLIHDF ICQGVGNALQ SEQADFARYD TPASADEIQE PAANWHSSLI
     KPNRSAAGHN IFESASDKNI SGANTYSHGS AKINRFSTKF AENIPHFSTK SVSKTEQKLY
     GNLLTTPAEA KKNTAINAES ENSFEKNVST PQQSTQLSGQ FLHSLALVKN QALLLQQGQD
     FYLLPLAKLQ KLKFELTLQQ PDIAQQPLLI PILFRLNERQ LAQWQKQKNF FLQSGFEFDE
     NPAQHRITLN KVPSCLRQQN LQGCVIRLLE ENHEKISDFL TALCNQLQLN EIHVLADALT
     LLTEVELLLK TQNKIQLAQL LISVDFTQYL Q