ID   MUTL_METLZ              Reviewed;         588 AA.
AC   A2SSN1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Mlab_1168;
OS   Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanocorpusculaceae; Methanocorpusculum.
OX   NCBI_TaxID=410358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43576 / DSM 4855 / Z;
RX   PubMed=21304657; DOI=10.4056/sigs.35575;
RA   Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L.,
RA   Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT   "Complete genome sequence of Methanocorpusculum labreanum type strain Z.";
RL   Stand. Genomic Sci. 1:197-203(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000559; ABN07337.1; -; Genomic_DNA.
DR   RefSeq; WP_011833540.1; NC_008942.1.
DR   AlphaFoldDB; A2SSN1; -.
DR   SMR; A2SSN1; -.
DR   STRING; 410358.Mlab_1168; -.
DR   PRIDE; A2SSN1; -.
DR   EnsemblBacteria; ABN07337; ABN07337; Mlab_1168.
DR   GeneID; 4795836; -.
DR   KEGG; mla:Mlab_1168; -.
DR   eggNOG; arCOG01166; Archaea.
DR   HOGENOM; CLU_004131_4_1_2; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 35865at2157; -.
DR   Proteomes; UP000000365; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..588
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010043"
SQ   SEQUENCE   588 AA;  64331 MW;  9EE01DE79CAC0CF1 CRC64;
     MSRVKILDEE TISHIAAGEV VERAASVVKE LVENAVDADA QIIRIGISAD KTGITKISVT
     DDGIGMDFDD ALLAFRQHAT SKISRPEDLD GITTLGFRGE ALASIAAISK VTFTTKERGS
     PSPEAARVVI HGGELISHSA VGAPEGTSVL IDALFYNTPA RRKFQKSVPT ELSHVYDMVE
     RIALSNRNIS FVLLYNGKER FQTFGTGSYP DVIAAVFGST FSKELTPVSG SFGPVKIDGW
     ITRPGSEMKT TQTRFYLSIN GRQVTSRQLQ WAIREGYGTL LPKGMYPAAF LDIVLDPRDV
     DVNVHPTKRE VRLSREREVM RCVQDAVYTS LHEERVFSTA PMPTLARETI TTLPVEIVGE
     PVPVYAGKQE MHEARQAPLK QTEKQLRRTE SADLPETDLF VPEVLGQIGD TYILAKNESG
     DLIVVDQHAA HERIMYDQLL ARSSSAEAGQ ELIVPQPITL SKKETAALPD LLDVLAAAGY
     LLEPFGKDVW MVRSVPVVSS TLGDPDTIHA ILDAALDGVG NTDEVLDRVL KTAACRAVVK
     GNTPLTIEQM QRLLRQLMAT KSPYTCPHGR PTTIVLSKSR LAGMFLRT