ID   MUTL_METMJ              Reviewed;         585 AA.
AC   A3CWX7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Memar_1951;
OS   Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX   NCBI_TaxID=368407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35101 / DSM 1498 / JR1;
RX   PubMed=21304656; DOI=10.4056/sigs.32535;
RA   Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A.,
RA   Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C.,
RA   Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L.,
RA   Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT   "Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981
RT   type strain JR1.";
RL   Stand. Genomic Sci. 1:189-196(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000562; ABN57877.1; -; Genomic_DNA.
DR   RefSeq; WP_011844786.1; NC_009051.1.
DR   AlphaFoldDB; A3CWX7; -.
DR   SMR; A3CWX7; -.
DR   STRING; 368407.Memar_1951; -.
DR   EnsemblBacteria; ABN57877; ABN57877; Memar_1951.
DR   GeneID; 4846347; -.
DR   KEGG; mem:Memar_1951; -.
DR   eggNOG; arCOG01166; Archaea.
DR   HOGENOM; CLU_004131_4_1_2; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 35865at2157; -.
DR   Proteomes; UP000002146; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..585
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010044"
SQ   SEQUENCE   585 AA;  62602 MW;  CD1B4C83FBD8809D CRC64;
     MTKIRVLDPD TVNQIAAGEV VERPASVVKE LLENAIDADS TSILIDVSSD MAAITKIRVT
     DNGEGMTPEE AVLAFHPHAT SKIRDIADLS AVRTLGFRGE ALASIAAVAE VTLVTRPRGG
     GALAGTRLVV RGGEIVEKSE VGAPEGTTIA VERLFYNTPA RRKFLKSRNT ELAHVYAVVE
     SLALAHGEVA FRVVHNGKER MATQRSGGAL NTIAGLYGAD LARSLVPVEG RLPFLAIRGY
     ISRPSESRGN PSQISVSING RSIASRQIAA AVREGYGTLL PKDRYPVAFL DLAIDTGLVD
     VNVHPTKREI RLSREREITG AIAAAVDEAL AGHDLARETP VEPVQQQIIA ADPGQVPTPS
     PVGEPGAPYT AGHRGLTLSD KQLRRTETEG GENLLPAMEP IGQVAATYIV AEGADGTLYL
     VDQHAAHERV LYDQVTEQRD KAAGSQELIT PVVLSLPPKE SAALRDAIPL LADEGFVVDE
     FGRDTFAVRA VPAALGAVED PGTVRETIAD LLADESRTAP DRRERVTCIV ACRGAVKAGA
     LLTPDQQKRL IMQLARTKTP WTCPHGRPTV VAFDRRRLDG MFRRG