ID   MUTL_METSB              Reviewed;         605 AA.
AC   B8ETE4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Msil_2869;
OS   Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB
OS   13906 / BL2).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Beijerinckiaceae; Methylocella.
OX   NCBI_TaxID=395965;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2;
RX   PubMed=20472789; DOI=10.1128/jb.00506-10;
RA   Chen Y., Crombie A., Rahman M.T., Dedysh S.N., Liesack W., Stott M.B.,
RA   Alam M., Theisen A.R., Murrell J.C., Dunfield P.F.;
RT   "Complete genome sequence of the aerobic facultative methanotroph
RT   Methylocella silvestris BL2.";
RL   J. Bacteriol. 192:3840-3841(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001280; ACK51786.1; -; Genomic_DNA.
DR   RefSeq; WP_012591855.1; NC_011666.1.
DR   AlphaFoldDB; B8ETE4; -.
DR   SMR; B8ETE4; -.
DR   STRING; 395965.Msil_2869; -.
DR   PRIDE; B8ETE4; -.
DR   EnsemblBacteria; ACK51786; ACK51786; Msil_2869.
DR   KEGG; msl:Msil_2869; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002257; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..605
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000123212"
SQ   SEQUENCE   605 AA;  64458 MW;  1778837F1C164589 CRC64;
     MPVRRLDPVL IDRIAAGEVI ERPASALKEL IENALDAGAR RIDVAIEAGG RKLIRVVDDG
     CGMAPEDLDL AVERHATSKL PEGDLSSIET LGFRGEALPS IGSVAALEIF SRAMGSAVGA
     RVKVDCGVKE GPAPAAQPQG TRVEIRDLFA GTPARLKFLR TDRAEARASA EIVERLAMAH
     PQVRFGFASS DVRGFDLAAC ADSPEGRLTR FSAVLGKDFR DNALFVEAER EGVRLQGFAG
     LPTWHRASAA AQHVFVNGRP VRDRLLLGAA RAAYMDFLPS GRHAALVLFL TCDPREVDVN
     VHPAKAEVRF RDPGLTRGLI VGALKQTLAD AQHRASPVNG ASALDVLARR GPGFSGAGGP
     ANWDWRRSPA NPGFDAAALA GFAEAPAAAF AAVESLAADT RANAAAPSLE DLEAPLGAAR
     AQIHETYIVS QTRDGIVIVD QHAAHERLVY ERLKAARAGS KAPRQALLIP AIVELARAEV
     EAILDAAVLL AEFGLIIEPF GPGAVAVTET PALLQDPDPT RLARDLAAAL VEDDGAAALE
     RRFNLVLATM ACHNSVRAGR RMRPEEMNAL LRDMERTPGS GQCNHGRPTY VELKLADVEK
     LFGRR