MUTL_METTP
ID MUTL_METTP Reviewed; 557 AA.
AC A0B977;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Mthe_1478;
OS Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 /
OS PT) (Methanosaeta thermophila).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=349307;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6194 / JCM 14653 / NBRC 101360 / PT;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C., Richardson P.;
RT "Complete sequence of Methanosaeta thermophila PT.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000477; ABK15251.1; -; Genomic_DNA.
DR AlphaFoldDB; A0B977; -.
DR SMR; A0B977; -.
DR STRING; 349307.Mthe_1478; -.
DR EnsemblBacteria; ABK15251; ABK15251; Mthe_1478.
DR KEGG; mtp:Mthe_1478; -.
DR HOGENOM; CLU_004131_4_2_2; -.
DR OMA; AHERIMY; -.
DR Proteomes; UP000000674; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..557
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000010045"
SQ SEQUENCE 557 AA; 61378 MW; 9002F317AFD48B50 CRC64;
MPRIHILDEE TVSRIAAGEV IERPASVVKE LIENSIDAGA SRIIIEVENG GISLIKLVDD
GCGIEREDLP LAFQRHATSK ISTADDLFRL KTLGFRGEAL SAIASVSKCV EVHTRTRYSP
VGTYLRLENG RVAEIKDDGC PYGTSIEVRG LFETIPARLK HLSSPSQELA RIAEIVTQMA
IIHHRISFEL SSGRRTLFRS NASETWDDAL IRAFGLRTAK GMISIIAEGD GFDLHGMISS
HDSSHHGSEL ILVYVNSRPV YSKVVVQALR EAYRGFLQSG RSPLAVISIE IEPSLVDVNV
HPAKREVRFL REDEVYDAVR DAALSALRSS AIPSPPPPAR IAEPQLWSAK PQIQRTLPLE
VQAEQRISEP LIRIVGQALD LYIIVEDDDG IMLVDQHAAA ERIRYEHLLE KCKSGSISQE
LIQPVTVELS PGEVALLDSF SGELGEIGFE IDPFGGRAYS VRSVPAAAGL ESPESIRDVL
REILNLGRVC RASFRDEALK HLACRGSIKS GERLSESAML RLLTDLFACD NPRTCPHGRP
VVVRISSESL EKMFGRR