ID   MUTL_MICAN              Reviewed;         550 AA.
AC   B0JS91;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=MAE_42270;
OS   Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Microcystaceae; Microcystis.
OX   NCBI_TaxID=449447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-843 / IAM M-247;
RX   PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA   Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA   Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA   Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA   Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT   "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT   Microcystis aeruginosa NIES-843.";
RL   DNA Res. 14:247-256(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP009552; BAG04049.1; -; Genomic_DNA.
DR   RefSeq; WP_012266901.1; NC_010296.1.
DR   AlphaFoldDB; B0JS91; -.
DR   SMR; B0JS91; -.
DR   STRING; 449447.MAE_42270; -.
DR   PaxDb; B0JS91; -.
DR   EnsemblBacteria; BAG04049; BAG04049; MAE_42270.
DR   KEGG; mar:MAE_42270; -.
DR   PATRIC; fig|449447.4.peg.3827; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_3; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; MAER449447:MAE_RS18315-MON; -.
DR   Proteomes; UP000001510; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..550
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096665"
SQ   SEQUENCE   550 AA;  62509 MW;  8B0CED5A531FB836 CRC64;
     MTLPIQVLPQ DVIDLIAAGE VIDSLGAVVR ELVENAIDAG ADRITIDISP QNWRIQVSDN
     GRGMSREDLQ LCSYAHSTSK IRQRDDLWQI TSLGFRGEAL HSIAQVAHLR VASRHDDDLG
     CYCLYNHQGE PGNLETIPIA IGTIVTVENL FGNFPVRRQA LPSINKQLKD IQTLIHNFAL
     CHPQITWQVF QDHQDWLRIS PGKDASQILP QLVKSLHFND LASLKLDLTT PDAESAQIEL
     VIGLPDRISR HQPDWVRIAV NGRMVRSSEL EQAIFEAFAR TVPKDRYPVC FLHLHLNPRS
     IDWNRHPAKA EIYLHNLIFW QEQIISAIDK ALGLNPEHIP EKAQNQRVSQ ILKAAEEKST
     YTIGEKSPKN RLELKAVAQI HQTYIVAEHP HGLWLVEQHI AHERVLYERL EDNWEIVPLD
     TPIILNQLTT RQIEQLQRLG LEIASFGDRS WAIRSIPVLL KEREDRADAL LELSLGGDLQ
     TAQVATACRS AIRNGTALSL KEMQNLLDDW QNTRNPRTCP HGRPIYLSLE ETSLARFFRR
     HWVIGKSHGI