ID   MUTL_MYXXD              Reviewed;         619 AA.
AC   Q1D568;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=MXAN_4026;
OS   Myxococcus xanthus (strain DK1622).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=246197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DK1622;
RX   PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA   Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA   Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA   Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA   Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT   "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000113; ABF90814.1; -; Genomic_DNA.
DR   RefSeq; WP_011554035.1; NC_008095.1.
DR   AlphaFoldDB; Q1D568; -.
DR   SMR; Q1D568; -.
DR   STRING; 246197.MXAN_4026; -.
DR   EnsemblBacteria; ABF90814; ABF90814; MXAN_4026.
DR   GeneID; 41361357; -.
DR   KEGG; mxa:MXAN_4026; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   OMA; VRVMACH; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002402; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..619
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076700"
SQ   SEQUENCE   619 AA;  65220 MW;  AC6DF120DF82A75D CRC64;
     MSRIARLSDV LINKIAAGEV VERPASVVKE LVENAIDAGA GTVRVELDGG GVDRIIVSDD
     GHGMGRSDAV ACLERHATSK LRELDDLFHI DSMGFRGEAI PAIASVSRFT LHSAAANSEV
     GTRVSVEGGG PPLVEDAPPR TGTVMTVEDL FFNVPARRKF LRRGDTELKH AEEAVVRLAL
     AYPEVGFFAS HEGGTLFSSA ACPDDPRERI AAALGSTSHP HLFPVEERRL GVAVTGFAAS
     PEFTFNNARG LYTFVNRRYI RDRGLIGTIQ RAYQDFLAAG RQPVVVLHID VDPRAVDVNV
     HPQKQEVRFA DARGVQEALT AALSRMLRAA PWLGSGVEGA APQAGQPMDA AHYAHAVERF
     LTRAQEAAWG GPLPTAMDAP GPGPGAPSLG PLGQGARPGA LPFAAAVGQA PAFGQAQPQL
     NEAPPPGYFG ALRPLGMLGG RFHVCEGPGG TLVVMDPHAA LERARLTGYL RALESGKPPP
     APTLFGTTLE LPVAAAKALV EGREALSRLG FDVEPFGGTT VALKTVPPGL EGADARSLLE
     ALARALPPKS ATLDTVSLAE AVRVMACHAA KQAGAVPLSD AQFRALLGEL DRADFHPTCS
     HGTVVVLEMP LLELERRAR