ID   MUTL_NEIG1              Reviewed;         658 AA.
AC   Q5F8M6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=NGO0744;
OS   Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=242231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700825 / FA 1090;
RA   Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F.,
RA   Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C.,
RA   Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H., Qi S.,
RA   Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.;
RT   "The complete genome sequence of Neisseria gonorrhoeae.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE004969; AAW89461.1; -; Genomic_DNA.
DR   RefSeq; WP_003698476.1; NC_002946.2.
DR   RefSeq; YP_207873.1; NC_002946.2.
DR   PDB; 3NCV; X-ray; 2.40 A; A/B=460-658.
DR   PDBsum; 3NCV; -.
DR   AlphaFoldDB; Q5F8M6; -.
DR   SMR; Q5F8M6; -.
DR   STRING; 242231.NGO_0744; -.
DR   EnsemblBacteria; AAW89461; AAW89461; NGO_0744.
DR   KEGG; ngo:NGO_0744; -.
DR   PATRIC; fig|242231.10.peg.886; -.
DR   HOGENOM; CLU_004131_4_2_4; -.
DR   OMA; AHERIMY; -.
DR   EvolutionaryTrace; Q5F8M6; -.
DR   Proteomes; UP000000535; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..658
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010046"
FT   REGION          114..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..387
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          469..474
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   TURN            475..477
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   STRAND          478..483
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   STRAND          486..491
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   HELIX           492..511
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   STRAND          516..526
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   HELIX           529..544
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   STRAND          548..550
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   STRAND          556..563
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   HELIX           571..582
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   HELIX           595..602
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   STRAND          606..608
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   HELIX           616..627
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   TURN            630..633
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   STRAND          640..646
FT                   /evidence="ECO:0007829|PDB:3NCV"
FT   HELIX           647..652
FT                   /evidence="ECO:0007829|PDB:3NCV"
SQ   SEQUENCE   658 AA;  71602 MW;  5B95436331D8C422 CRC64;
     MPRIAALPDH LVNQIAAGEV VERPANALKE IVENSIDAGA TAVDVELEGG GIRLIRVGDN
     GGGIHPDDIE LALHRHATSK IKTLNDLEHV ASMGFRGEGL ASIASVSRLT LTSRQEDSSH
     ATQVKAEDGK LSSPTAAAHP VGTTIEAAEL FFNTPARRKF LKSENTEYAH CATMLERLAL
     AHPHIAFSLK RDGKQVFKLP AQSLHERIAA IVGDDFQTAS LEIDSGNSAL RLYGAIAKPT
     FAKGKTDKQY CFVNHRFVRD KVMLHAVKQA YRDVLHNALT PAFVLFLELP PEAVDVNVHP
     TKTEIRFRDS RQVHQLVFHT LNKALADTRA NLTESVSNAG EVLHDITGVT PAPMPSENDG
     ENLFDSASNH PTGNKPDTRN AFGSSGKTAP MPYQAARAPQ QHSLSLRESR AAMDTYAELY
     KKTDDIDLEL SQFEQARFGN MPSETPAHKT DTPLSDGIPS QSELPPLGFA IAQLLGIYIL
     AQAEDSLLLI DMHAAAERVN YEKMKRQRQE NGNLQSQHLL IPVTFAASHE ECAALADHAE
     TLAGFGLELS DMGGNTLAVR AAPVMLGKSD VVSLARDVLG ELAQVGSSQT IASHENRILA
     TMSCHGSIRA GRRLTLPEMN ALLRDMENTP RSNQCNHGRP TWVKLTLKEL DTLFLRGQ