ID   MUTL_NEIMA              Reviewed;         658 AA.
AC   Q9JTS2; A1ISN0;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=NMA1655;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AL157959; CAM08789.1; -; Genomic_DNA.
DR   PIR; C81860; C81860.
DR   RefSeq; WP_002251827.1; NC_003116.1.
DR   AlphaFoldDB; Q9JTS2; -.
DR   SMR; Q9JTS2; -.
DR   EnsemblBacteria; CAM08789; CAM08789; NMA1655.
DR   KEGG; nma:NMA1655; -.
DR   HOGENOM; CLU_004131_4_2_4; -.
DR   OMA; AHERIMY; -.
DR   BioCyc; NMEN122587:NMA_RS08275-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..658
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177955"
FT   REGION          114..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          438..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  71842 MW;  76B33C9628F63506 CRC64;
     MPRIAALPDH LVNQIAAGEV VERPANALKE IVENSIDAGA TAIDVELDGG GIRLIRVSDN
     GSGIHPDDIE LALHRHATSK IKTLNDLEHV ASMGFRGEGL ASIASVSRLT LTSRQEDSSH
     ATQVKAEDGK LSSPTAAAHP VGTTIEAAEL FFNTPARRKF LKSENTEYAH CATMIERLAL
     AHPHIAFSLK RDGKQVFKLP AQSLHERIAA IVGDDFQTAS LEIDSGSGAL RLYGAIAKPT
     FAKGKTDKQY CFVNHRFVRD KVMLHAVKQA YRDVLHNALT PAFVLFLDLP PEAVDVNVHP
     TKTEIRFRDS RQVHQLVFHT LNKALADTRA DLTESVSNAG EVLHDITGVT PAPMPSENDS
     ENLFNRASDY PTGNKPDTRN AFGSSGKTAP MPYQSAYAPQ QRSLSLRESR AAMNTYAELY
     KKTDDIDLEL SQFEQARFGN MPSETPAPKT DTPLSDGIPS QSELPPLGFA IAQLLGIYIL
     AQAEDSLLLI DMHAAAERVN YEKMKRQRQE NGRLQSQRLL IPITFAASHE ECAALADYAE
     TLAGFGLELS DMGGNTLAVR AVPTMLGKAD VVSLARDVLG ELAQVGSSQT IEEHENHILA
     TMSCHGSVRA GRQLTLPEMN ALLRDMENTP RSNQCNHGRP TWVKLTLKEL DALFLRGQ