ID   MUTL_NEIMB              Reviewed;         658 AA.
AC   Q9JYT2;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=NMB1442;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE002098; AAF41803.1; -; Genomic_DNA.
DR   PIR; B81084; B81084.
DR   RefSeq; NP_274454.1; NC_003112.2.
DR   RefSeq; WP_002222285.1; NC_003112.2.
DR   AlphaFoldDB; Q9JYT2; -.
DR   SMR; Q9JYT2; -.
DR   STRING; 122586.NMB1442; -.
DR   PaxDb; Q9JYT2; -.
DR   EnsemblBacteria; AAF41803; AAF41803; NMB1442.
DR   KEGG; nme:NMB1442; -.
DR   PATRIC; fig|122586.8.peg.1811; -.
DR   HOGENOM; CLU_004131_4_2_4; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..658
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177956"
FT   REGION          114..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  71647 MW;  40EEDC060396DD2F CRC64;
     MSRIAALPDH LVNQIAAGEV VERPANALKE IVENSIDAGA TAIEVELAGG GIRLIRVSDN
     GGGIHPDDIE LALHRHATSK IKTLNDLEHV ASMGFRGEGL ASIASVSRLT LTSRQNDSSH
     ATQVKAEDGK LSSPTAAAHP VGTTIEAAEL FFNTPARRKF LKSENTEYAH CATMLERLAL
     AHPHIAFSLK RDGKQVFKLP AQSLHERIAA IVGEDFQTAS LGIDSGNGAL RLYGAIAKPT
     FAKGKTDKQY CFVNHRFVRD KVMLHAVKQA YRDVLHNALT PAFVLFLDLP PEAVDVNVHP
     TKTEIRFRDS QQVHQLVFHT LNKALADTRA NLTESVGNAG EVLHDITGVV STPMPSENDS
     ENLFDSVSNY PTGNKSDTHN AFGSSGKTAP MPYQSAYAPQ QRSLSLRESR AAMNTYAELY
     KKTDDIDLEL SRFEQARFGN MPSETPAPQT DTPLSDGIPS QSELPPLGFA IAQLLGIYIL
     AQAEDSLLLI DMHAAAERVN YEKMKRQRQE NGNLQSQRLL IPVTFAASHE ECAALADYAE
     TLAGFGLELS DMGGNTLAVR AVPAMLGKAD VVSLAKDVLN ELAQVGSSQT IEEHENRILA
     TMSCHGSIRA GRRLTLPEMN ALLRDMENTP RSNQCNHGRP TWVKLTLKEL DALFLRGQ