ID   MUTL_NITWN              Reviewed;         603 AA.
AC   Q3SPJ0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Nwi_2548;
OS   Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 /
OS   NCIMB 11846 / Nb-255).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Nitrobacter.
OX   NCBI_TaxID=323098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255;
RX   PubMed=16517654; DOI=10.1128/aem.72.3.2050-2063.2006;
RA   Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L.,
RA   Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J.,
RA   Hickey W.J.;
RT   "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium
RT   Nitrobacter winogradskyi Nb-255.";
RL   Appl. Environ. Microbiol. 72:2050-2063(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000115; ABA05801.1; -; Genomic_DNA.
DR   RefSeq; WP_011315752.1; NC_007406.1.
DR   AlphaFoldDB; Q3SPJ0; -.
DR   SMR; Q3SPJ0; -.
DR   STRING; 323098.Nwi_2548; -.
DR   EnsemblBacteria; ABA05801; ABA05801; Nwi_2548.
DR   KEGG; nwi:Nwi_2548; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002531; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..603
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010050"
SQ   SEQUENCE   603 AA;  65288 MW;  04016129BCDBA83B CRC64;
     MPVRQLPETV VNRIAAGEVV ERPASVVKEL VENAIDAGAT RIDVFTDGGG RRRIGVTDDG
     AGMAKGDLAL AVDRHATSKL DDEDLLGIRT LGFRGEALPS IGAVARLCIT TREAREPHAW
     SLTVEGGRKS EIIPAALTNG TRVEVGDLFY ATPARLKFLK TDRTEAEAIR EVVRRLAMAR
     PDIGFTLAGE ERAPVTWTAA LPGAAGRLTR LGDILGGDFR AAAIPVRAER EGVIVEGFAA
     APSLTRANAL GQYLFVNGRP VRDKLILGAV RAAYSDYLPR DRHPVAALFV TADPREVDAN
     VHPAKTEVRF RNAGLVRALI VHALKEGLAR EGRRTAANRD GAVLTAFRPA PSPRPANWDW
     RESPAAPADA RPWIGGPPAA AFAEAGQAAL DVGAPSADVR FDAHPPLDLV DRPLGAARTQ
     IHETYIVSQT RDGLIVVDQH AAHERIVYER LKTALARDGV QRQILLIPDI VELDEATVEK
     LIDRATELEK FGLAIESFGP GAVAVRETPS LLGKINAAAL LRDLAEHMTE WEETLPLERR
     LMHVAATMAC HGSVRAGRIL KPEEMNALLR EMEATPNSGQ CNHGRPTYVE LKLDDIEKLF
     GRR