ID   MUTL_NOSP7              Reviewed;         568 AA.
AC   B2IYW1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Npun_F3251;
OS   Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=63737;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29133 / PCC 73102;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA   Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT   "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001037; ACC81694.1; -; Genomic_DNA.
DR   RefSeq; WP_012409673.1; NC_010628.1.
DR   AlphaFoldDB; B2IYW1; -.
DR   SMR; B2IYW1; -.
DR   STRING; 63737.Npun_F3251; -.
DR   EnsemblBacteria; ACC81694; ACC81694; Npun_F3251.
DR   KEGG; npu:Npun_F3251; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_3; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   PhylomeDB; B2IYW1; -.
DR   Proteomes; UP000001191; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..568
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096667"
SQ   SEQUENCE   568 AA;  63655 MW;  55A2B4C38EB66E25 CRC64;
     MASIIQALPT EVVYLITAGE VIDSLASVVR ELVENSLDAG ATRIVVSLWP QQWRIRVADN
     GCGMNLDDLQ QAATAHSTSK IRSSADLWKI NSLGFRGEAL HSLTTLADLE ILSRPVDGKL
     GWRISYGNGG KVVQVEVTAI APGTVVTVSN LFGNCSSRRQ GLPTTAQQMK AVQATIYQIA
     LCHPHVTWQI WQNDRQWFTI SPARTTGQLL PQILPQVRQG DLQEVKLEIP NPPHSPLPCT
     NAIHRVSPHS ALTLVVGLPD RCHRHRPDWV RVAINGRMVK TPELEQTILS AFHRTLPRDR
     YPICFLHLAI SPDQINWNRN PAKTEIYLNE IIYWQEQITQ AINQALSISS SNLKEAVHTT
     RVSKLLKAAE AKGGYNFNPQ NPKEDRKNPN SLKAVAQVSN TYIVAEHPGG MWLVEQHIAH
     ERVLYEQLCD DWQLVPVEPP IILYQLSLAQ VSQLQRIGLD IESFGEQLWA VRNIPAPLQQ
     RDDCAEAILE LSWGGDLQTA QVAVACRSAI RNGTPMNQQE MQTLLDNWQR TRNPRTCPHG
     RPIYLSLEES ALARFFRRNW VIGKSHGI