ID   MUTL_NOSS1              Reviewed;         563 AA.
AC   Q8YSM9;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=alr3055;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; BA000019; BAB74754.1; -; Genomic_DNA.
DR   PIR; AH2187; AH2187.
DR   RefSeq; WP_010997206.1; NZ_RSCN01000001.1.
DR   AlphaFoldDB; Q8YSM9; -.
DR   SMR; Q8YSM9; -.
DR   STRING; 103690.17132149; -.
DR   PRIDE; Q8YSM9; -.
DR   EnsemblBacteria; BAB74754; BAB74754; BAB74754.
DR   KEGG; ana:alr3055; -.
DR   eggNOG; COG0323; Bacteria.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..563
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177923"
SQ   SEQUENCE   563 AA;  63155 MW;  248A53163C9C5485 CRC64;
     MASTIQALPQ EVVYLITAGE VIDSFAAVVR ELVENSLDAG ANRIVVYLWP QQWRVRVADN
     GCGMNLDDLQ QAASAHSTSK IRSSADLWKI HSLGFRGEAL HSLTTLADVE IISRAPENVG
     WRVVYGDSGK AVHVEATAIA PGTVVTVSNL FASCAARRQG LPTTAQQMKA VQATIQQIAL
     CHPQTTWQVW QNDRIWFTIS PAATAGQLIP QFLPQLRPSD LQEIKLEIPN PENPQLSTNN
     KPNASALALV VGLPDRCHRH RPDWVRVAIN GRMIKLPELE QTILAAFHRT LPRDRYPLCF
     VHLLISPDQI NWNRNPAKTE IYLHDLSYWQ EQVTQAINQA LRISAANIPE SVQTTRVSQL
     LKAAEEKGNY NFNPRNANPA DNTQNYLKAV AQVSNTYIVA EHPGGMWLVE QHIAHERVLY
     EQLCDNWRLI PVEPPIILYQ LSPAQVAQLQ RIGLDIDIFG EQLWAVRNLP AMLQQREDCA
     EAILELSWGG DLQTAQVAVA CRSAIRNGTP MSLPEMQKLL DDWQRTRNPR TCPHGRPIYL
     SLDESSLSRF FRRHWVIGKS HGI