ID   MUTL_OPITP              Reviewed;         628 AA.
AC   B1ZZY2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Oter_4044;
OS   Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1).
OC   Bacteria; Verrucomicrobia; Opitutae; Opitutales; Opitutaceae; Opitutus.
OX   NCBI_TaxID=452637;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11246 / JCM 15787 / PB90-1;
RX   PubMed=21398538; DOI=10.1128/jb.00228-11;
RA   van Passel M.W., Kant R., Palva A., Copeland A., Lucas S., Lapidus A.,
RA   Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J.,
RA   Larimer F.W., Land M.L., Hauser L., Kyrpides N., Mikhailova N.,
RA   Richardson P.P., Janssen P.H., de Vos W.M., Smidt H.;
RT   "Genome sequence of the verrucomicrobium Opitutus terrae PB90-1, an
RT   abundant inhabitant of rice paddy soil ecosystems.";
RL   J. Bacteriol. 193:2367-2368(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001032; ACB77318.1; -; Genomic_DNA.
DR   RefSeq; WP_012376846.1; NC_010571.1.
DR   AlphaFoldDB; B1ZZY2; -.
DR   SMR; B1ZZY2; -.
DR   STRING; 452637.Oter_4044; -.
DR   PRIDE; B1ZZY2; -.
DR   EnsemblBacteria; ACB77318; ACB77318; Oter_4044.
DR   KEGG; ote:Oter_4044; -.
DR   eggNOG; COG0323; Bacteria.
DR   eggNOG; COG3170; Bacteria.
DR   HOGENOM; CLU_004131_4_2_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000007013; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..628
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096669"
FT   REGION          334..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  68500 MW;  87F9E5808EA6A015 CRC64;
     MAKVRILSDR VANQIAAGEV IERPAAVVKE LVENALDAGA TRIEVEFRHG GRSLMRVEDN
     GSGMSRDDAL LALERHATSK ISEAADLDRL GSYGFRGEAL PSIASVSRFE LQTREAGQNV
     GTEVLVSGGK LVHVRDCGRP VGTRIEVAQL FNSVPARRKF LKSDQTEAAH IVQCVRLYAL
     ACPGTAFSLI EDGRVIFRSP ECPTLAERIA EIFGRQTAES LVPIESVESG MRLGGLIGRP
     GVGRGTRHEM IVFVNQRPVD SRTLNYALIE SYYESVPKGR YPLAFVFFEC DPAAVDVNVH
     PAKREVRFRN EPAVRSFVIR SVLQRLREIA DHRSDFAQPS ADNMPKPESP GAPAAHGRKD
     DAPAAHAEGR AATPLAAGNL IVTARFGAES TPYLEKSGAI AGARPAGVLP PAVPRIPAAP
     MPVNAGAAAV PAPLKPASPS WRFVGLAHGN YALFETTAGL ILLDRRAAHE RVWFERLQEQ
     FRSGAVPSQR LLLPVPVELD PIAAALLLDR VQFLNAHGFE IAEFGRNFFR IEAVPAWMEP
     ADAEPFLRDL LGAFREGHWP DRDANLAREE LARLASVKAV RLPAVTGEQE LRALVTHLFA
     TRTPMTNPAG RPTYIELNHA ELARRFQK