ID   MUTL_PARD8              Reviewed;         615 AA.
AC   A6LEJ8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BDI_2387;
OS   Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS   5825 / NCTC 11152).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Parabacteroides.
OX   NCBI_TaxID=435591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000140; ABR44112.1; -; Genomic_DNA.
DR   RefSeq; WP_005853950.1; NZ_LR215978.1.
DR   AlphaFoldDB; A6LEJ8; -.
DR   SMR; A6LEJ8; -.
DR   STRING; 435591.BDI_2387; -.
DR   EnsemblBacteria; ABR44112; ABR44112; BDI_2387.
DR   KEGG; pdi:BDI_2387; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; PDIS435591:G1G5A-2453-MON; -.
DR   Proteomes; UP000000566; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..615
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000058146"
SQ   SEQUENCE   615 AA;  68349 MW;  19232A5CBDA77AA6 CRC64;
     MSDIIHLLPD HIANQIAAGE VIQRPASVVK ELVENAVDAG ASNIQVNIKD AGKTLIQVID
     DGKGMSETDA RMAFERHATS KISTAEDLFS LHTMGFRGEA LASIAAVAHI ELRTRARGTE
     LGTCLSIAGS NLESIEPEAC NEGSIFSVKN LFFNVPARRK FLKSNETEFR NIINEFERIA
     LVNPQVGMSL YHNDAEIFNL PESGLRQRII NIYGKSLNQK LLSLDAQSSM VTISGFVGRP
     DSAKKRGALQ FFFVNGRYMK HPYFHKAIMQ AYEQLIPAGD MPNYFVYFTL DPSSIDVNIH
     PTKTEIKFEN EQPIWQILMA ATREALAKSS AIPTIDFDVE DAIDIPVYNP VKKSEPSTYK
     APKVQVDSSY NPFDTTSYKK PEFDWSKLYQ GFENDRVAVQ RESETFEDAP IEELPAEASD
     PEKLFTEVSN PCYQYKGRYI VTSLKSGLAI IDQHRAHVRI LFDQYLSNIR QQQGVSQQVL
     FPEIVEFTAA EAAVLPSLLE DLCFVGFDLS NLGNDNYAIN GLPAGIENLD PVNLVKDIVD
     RAIETGCAVH EKICEAIALS LAKAAAIRPG KSLSLEEMDH LIASLFSCSD SNLTPDGKTI
     ISMLTDEELE RRFKC