ID   MUTL_PASMU              Reviewed;         617 AA.
AC   P57886;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=PM0904;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; AE004439; AAK02988.1; -; Genomic_DNA.
DR   RefSeq; WP_010906909.1; NC_002663.1.
DR   AlphaFoldDB; P57886; -.
DR   SMR; P57886; -.
DR   STRING; 747.DR93_1746; -.
DR   EnsemblBacteria; AAK02988; AAK02988; PM0904.
DR   KEGG; pmu:PM0904; -.
DR   PATRIC; fig|272843.6.peg.914; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; WKHDDLH; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..617
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177957"
SQ   SEQUENCE   617 AA;  69798 MW;  8DC85F15695460AE CRC64;
     MAIKVLSPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIQIDIENGG STLIRIRDNG
     IGIAKDELSL ALARHATSKI ASLDDLDNIL SLGFRGEALA SISSVSRLTL TSRPATQNEA
     WQVYAQGREM ETTLQPASHP VGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL
     AKMAISFTLT HNGKIVRQYR SAHDRTQKLK RVAAICGDEF VQNALEIDWK HDDLHLSGWV
     AQPTFSRTQN DLSYCYINGR MVRDKIITHA IRQAYADFLS PEQYPAFVLF IDLNPNDVDV
     NVHPTKHEVR FHQQRLVHDF ICQGISNALH SEQASLYQTN EACVSANYQV EESAQHEYRP
     SYSKPNRAAA GQNIFDSSTT TPSTALFQTN KKNTQNRPHF STNIPATRIS KTEQAAYSAL
     LSNSEMATVL PQEDGALLER KTPSILKALA LVENKALLLQ QQQQFYLLSL QQLQRLKIEL
     SLQRDPVLQQ PLLIPIVFRL NPQQLTYWQQ QKTFFTQIGF EFHENLGQQR ITLNRVPSCL
     RQQNLQKCII VLLSQPLDTF SHFLTTLCDV IELEQITVYA DAVTLLTETE QLLNQKQAIR
     LSELFIELNW QAYLEKM