ID   MUTL_PECCP              Reviewed;         669 AA.
AC   C6DFJ9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PC1_3723;
OS   Pectobacterium carotovorum subsp. carotovorum (strain PC1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=561230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001657; ACT14738.1; -; Genomic_DNA.
DR   RefSeq; WP_015841850.1; NC_012917.1.
DR   AlphaFoldDB; C6DFJ9; -.
DR   SMR; C6DFJ9; -.
DR   STRING; 561230.PC1_3723; -.
DR   EnsemblBacteria; ACT14738; ACT14738; PC1_3723.
DR   KEGG; pct:PC1_3723; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; YLANYQT; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002736; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..669
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203393"
FT   REGION          354..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..479
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   669 AA;  73810 MW;  570B206537AAEE62 CRC64;
     MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
     SGIGKDELTL ALARHATSKI ATLDDLEAIV SMGFRGEALA SISSVSRLTL TSRTAEQSEA
     WQAYAEGRDM AVTVKPAAHP VGTTLEVLDL FYNTPARRKF MRTEKTEFTH IDEVVRRIAL
     ARFDVAITLH HNGKLIRQYR AAPDKSQYER RLGNICGATF LQHALAVSWQ HGDLTIHGWV
     ADPVGAKQLP DMQYCYVNQR MMRDRLINHA IRQAYQDQLS DDQQPAYVLY LEIDPHQVDV
     NVHPAKHEVR FHQARLVHDF IYQAVMSVLQ QASAPGLGMT SPETGKPVQW QQENRPAAGE
     NHFAQPPRTD NSPSYGGKTP RAGHSGQAKE SAYSGYQPEN PYQKKQGDLY KALLQPADGA
     AGASNPSGEH ISVPANRVMP PEVVVLSTVS HDSPPNRTAP DATTSSSKPR APIESPLESQ
     SNGFGRVLTV YPPCYALLEY HKGLAMLSLS VAERHLKAVQ LTPSEEGLRA QPLLIPQRLT
     LSKSELSVLS AHHALLARFG IDVLVESQRA TLRAVPLPLR QQNLQNLISE LIGYLANYQT
     VETQQVEPGE LASWMATRLQ SEQESWSHSQ AIQLLADVER LCPQLAKAPP SELLYMMDIH
     DAIKALKHE