ID   MUTL_PEDPA              Reviewed;         645 AA.
AC   Q03EQ8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PEPE_1273;
OS   Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 /
OS   183-1w).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Pediococcus.
OX   NCBI_TaxID=278197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000422; ABJ68314.1; -; Genomic_DNA.
DR   RefSeq; WP_011673583.1; NC_008525.1.
DR   AlphaFoldDB; Q03EQ8; -.
DR   SMR; Q03EQ8; -.
DR   STRING; 278197.PEPE_1273; -.
DR   PRIDE; Q03EQ8; -.
DR   EnsemblBacteria; ABJ68314; ABJ68314; PEPE_1273.
DR   GeneID; 33061706; -.
DR   KEGG; ppe:PEPE_1273; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000773; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..645
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010052"
SQ   SEQUENCE   645 AA;  72566 MW;  4FE9CEB11A4E6020 CRC64;
     MAEIHELSEI LADQIAAGEV VERPASVVKE LVENAIDAGS SRIDILLEES GLKMIRIIDN
     GSGIDANQVE IAFKRHATSK ISSRSDLFKV GTLGFRGEAL PSIASIADVE MLTATTDGPG
     KKIHYRGGKL EDSGDAQSRQ GTDITVQDLF FNTPARLKYL KSLQTELSKI TDIVNRIALS
     YPEVAISLQN NERELMRTSG NGNIQQVLAN IYGAKNAQKM VHVKEQNIDF TIDGYISLPE
     FTRANRSYIT VLVNGRYIKN FQISKAIIDG YGSKLMVGRY PVAVLNIKTD PILVDVNVHP
     TKQEVRISEE QTLLDLISKA VFNELADKNL IPDAVDNLKK SRVKVSSSEQ LDLARMAISG
     SFEMEQDHVT IPDTDNDEVE KEVNISDRYV EPEPIVINSR QDLKSDTIAE FKTKYANDAV
     VNNTVEDGDQ PELKEKDAVQ RFPTLTYIGQ MHGTYLFAEA EDGLYIIDQH AAQERINYEY
     YRVQIGEVSD DQQDLLVPIY LDYSTTDAIR IKEKQTVLES CGLFLEEFGK NTFIVRHHPT
     WFKKGQEEDT VKEMVDYVLN DSSMTVAKFR EATAIMMSCK RAIKANHHLD EPQAKQLLKD
     IAKAENPFNC PHGRPVLVHF STTDMEKMFK RIQDPHHSDL MEDEM