ID   MUTL_PELPB              Reviewed;         626 AA.
AC   B4SGC3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Ppha_2701;
OS   Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Pelodictyon.
OX   NCBI_TaxID=324925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5477 / BU-1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F., Overmann J.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of Pelodictyon phaeoclathratiforme BU-1.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001110; ACF44859.1; -; Genomic_DNA.
DR   RefSeq; WP_012509331.1; NC_011060.1.
DR   AlphaFoldDB; B4SGC3; -.
DR   SMR; B4SGC3; -.
DR   STRING; 324925.Ppha_2701; -.
DR   EnsemblBacteria; ACF44859; ACF44859; Ppha_2701.
DR   KEGG; pph:Ppha_2701; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002724; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..626
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096670"
SQ   SEQUENCE   626 AA;  71297 MW;  790270BE67078C90 CRC64;
     MARIARLPDI VANKISAGEV VQRPASVVKE LLENAIDAGA DKITVAIKDA GKELIRIVDN
     GAGMLREDAL LCVERFATSK ITGVDDLDSL QSLGFRGEAL ASISSVSHFE LKTRTAKATL
     GLRLRYEGGV LVEESGVQGE QGTTISVRNL FYNVPARRKF LKSNATEYNH IFEIVKSFAL
     AYPEIEWRMY SDDEELFHVK RPDILERLNV FYGDDFAASM IELSEENDYL SIKGYLGKPA
     MQKRRKLDQY FFVNRRVVQN RMLSQAVQQA YGDLLVERQT PFVLLFLTID PSRIDVNVHP
     AKMEIRFDDE RNVRNMFYPV IKRAIQLHDF SPDLVSTECD QLSSLQPQNS AFRKFSFPDI
     PHRSITTGDL YRNYREGAVD EPAISRVASA HQGEMFPRHS SADYALAGSG LREGDEGLSS
     ILLAPLYDDD VVPNPKEVEP KIWQLHNKYL ICQIKTGLMI IDQHVAHERV LYERAVDVMN
     QNVPNSQQLL FPQKVEFRPW EYEIFEEIRE DLYRLGFNLR LFGNKTIMIE GVPQDVKPGS
     EVTILQDMIA EYQDNASKLK LDKRDNLAKS YSCRNAIMAG QKLSLEEMRS LIDNLFATRE
     PYSCPHGRPV IIKLSLDQLD KMFGRK