ID   MUTL_PELTS              Reviewed;         605 AA.
AC   A5D2K5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PTH_1342;
OS   Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Desulfotomaculaceae;
OC   Pelotomaculum.
OX   NCBI_TaxID=370438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13744 / JCM 10971 / SI;
RX   PubMed=18218977; DOI=10.1101/gr.7136508;
RA   Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.;
RT   "The genome of Pelotomaculum thermopropionicum reveals niche-associated
RT   evolution in anaerobic microbiota.";
RL   Genome Res. 18:442-448(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP009389; BAF59523.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5D2K5; -.
DR   SMR; A5D2K5; -.
DR   STRING; 370438.PTH_1342; -.
DR   PRIDE; A5D2K5; -.
DR   EnsemblBacteria; BAF59523; BAF59523; PTH_1342.
DR   KEGG; pth:PTH_1342; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000006556; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..605
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076702"
SQ   SEQUENCE   605 AA;  65045 MW;  E368CE816CF342D4 CRC64;
     MANIIILDEF TAGQIAAGEV VERPVSVVKE LVENSIDAGA GRIVVELEGG GLQAISVLDD
     GCGMSEEDLV LAFQRHATSK IKCSDDLNRI TTLGFRGEAL PSIAAVSKIT VATRTRDALA
     GTRAEFAGGE LIGKGPIGCP PGTSITVRDL FYNTPARRKA MKAPSAEGAL CGGLISRLAL
     ARPEICFEVG IKGRRVFYSP GSGNLIDSLA AVYGRQIAAE MIAVKAVAEG LSINGYLGKP
     SLSRSTRSHI TVIINGRYVR CPAIAEAIEG AYGTLLSRGR RPVAVLSLSV SPELLDVNIH
     PAKLEVRLLE EEKTASLLAG ILKDALADKA VIPSAGNFRQ AALRLENNKP GAEIFDGLGA
     GIIKTPGGGS SDRHVPGDKK NIQECLTLPD AHEYVADRVW VREAEDTPAY GNKVEKLPVL
     NALAHFPPVY ILAGGEDGLY IVDQHAAHER IIYEEILSSG RTRPSQYLLV PVMLELDYRE
     ASILIERIIW FTDAGFVIEH FGGNTFLLRG VPFELPAGQE REIILDLLDY FESKGTGAGM
     TDFFKWAAAS IACRSAVRAG EKLSLPSMNA LLQRLSGTAS PYTCPHGRPV VIKLSFRELE
     LRFRR