MUTL_PETMO
ID MUTL_PETMO Reviewed; 621 AA.
AC A9BJB9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Pmob_0599;
OS Petrotoga mobilis (strain DSM 10674 / SJ95).
OC Bacteria; Thermotogae; Petrotogales; Petrotogaceae; Petrotoga.
OX NCBI_TaxID=403833;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10674 / SJ95;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Noll K., Richardson P.;
RT "Complete sequence of Petroga mobilis SJ95.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000879; ABX31333.1; -; Genomic_DNA.
DR RefSeq; WP_012208437.1; NC_010003.1.
DR AlphaFoldDB; A9BJB9; -.
DR SMR; A9BJB9; -.
DR STRING; 403833.Pmob_0599; -.
DR EnsemblBacteria; ABX31333; ABX31333; Pmob_0599.
DR KEGG; pmo:Pmob_0599; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_0; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000000789; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..621
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000076703"
SQ SEQUENCE 621 AA; 71151 MW; C7E405439F6EB500 CRC64;
MRIKVLNPEV VMKIAAGEVV SGPSSVVKEL VENSLDAQAD SITVEILDGG KSLIKVDDNG
IGMEEEELEL SILPHTTSKI FSIEDLYKLK TFGFRGEALS SISRVSRMKM TSKPPEKEVG
TMLEILGGKI IEKKRVNSSN GTKIEIMDLF FNIPARRKFL KSDSAEGRYV TEIIEKFAFT
NNINLTYIRD HKEIYKFSSD MDLITKCLKI YPELKRDDLI EIEHNDSLCK ISGVISQPKV
GRNNRTAQHF FVNNRYIKVA SLYSVLETGY GEILEKSIHP YGIIFIEIPP DMVDVNVHPQ
KLEVKFTDEQ MVASLLKKVV RESLKKNTHF TMEFINSNDT IDLNKKTSSF SVQNLYNKNE
SSQKVDFSQN PTNTDYFENT DEFFNNSEIE DLQEEQNHFD NSYKLYEPSK TFDFKGFEYQ
KNQTFTPVEK INSLEKLRIL GIVAERYLVV EGEDKLLLVD FHAAHERYIY EILRENVYEK
GGLTSDLLLT PVIIALDEVR KGIILENKDH LEKLGIKLEE DEKEIIVKGL PSLVKIDDAE
RLIFEIADDL RISNFDQQPN ILDKNLATMA CRAAVKTRDN PTGMETLLNT IFEKKLLTCP
HGRPIMIQIT FKTLDKYFGR I