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MUTL_PETMO
ID   MUTL_PETMO              Reviewed;         621 AA.
AC   A9BJB9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Pmob_0599;
OS   Petrotoga mobilis (strain DSM 10674 / SJ95).
OC   Bacteria; Thermotogae; Petrotogales; Petrotogaceae; Petrotoga.
OX   NCBI_TaxID=403833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10674 / SJ95;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Noll K., Richardson P.;
RT   "Complete sequence of Petroga mobilis SJ95.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000879; ABX31333.1; -; Genomic_DNA.
DR   RefSeq; WP_012208437.1; NC_010003.1.
DR   AlphaFoldDB; A9BJB9; -.
DR   SMR; A9BJB9; -.
DR   STRING; 403833.Pmob_0599; -.
DR   EnsemblBacteria; ABX31333; ABX31333; Pmob_0599.
DR   KEGG; pmo:Pmob_0599; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000789; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..621
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076703"
SQ   SEQUENCE   621 AA;  71151 MW;  C7E405439F6EB500 CRC64;
     MRIKVLNPEV VMKIAAGEVV SGPSSVVKEL VENSLDAQAD SITVEILDGG KSLIKVDDNG
     IGMEEEELEL SILPHTTSKI FSIEDLYKLK TFGFRGEALS SISRVSRMKM TSKPPEKEVG
     TMLEILGGKI IEKKRVNSSN GTKIEIMDLF FNIPARRKFL KSDSAEGRYV TEIIEKFAFT
     NNINLTYIRD HKEIYKFSSD MDLITKCLKI YPELKRDDLI EIEHNDSLCK ISGVISQPKV
     GRNNRTAQHF FVNNRYIKVA SLYSVLETGY GEILEKSIHP YGIIFIEIPP DMVDVNVHPQ
     KLEVKFTDEQ MVASLLKKVV RESLKKNTHF TMEFINSNDT IDLNKKTSSF SVQNLYNKNE
     SSQKVDFSQN PTNTDYFENT DEFFNNSEIE DLQEEQNHFD NSYKLYEPSK TFDFKGFEYQ
     KNQTFTPVEK INSLEKLRIL GIVAERYLVV EGEDKLLLVD FHAAHERYIY EILRENVYEK
     GGLTSDLLLT PVIIALDEVR KGIILENKDH LEKLGIKLEE DEKEIIVKGL PSLVKIDDAE
     RLIFEIADDL RISNFDQQPN ILDKNLATMA CRAAVKTRDN PTGMETLLNT IFEKKLLTCP
     HGRPIMIQIT FKTLDKYFGR I
 
 
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