ID   MUTL_PHEZH              Reviewed;         622 AA.
AC   B4RA70;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PHZ_c3165;
OS   Phenylobacterium zucineum (strain HLK1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Phenylobacterium.
OX   NCBI_TaxID=450851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HLK1;
RX   PubMed=18700039; DOI=10.1186/1471-2164-9-386;
RA   Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.;
RT   "Complete genome of Phenylobacterium zucineum - a novel facultative
RT   intracellular bacterium isolated from human erythroleukemia cell line
RT   K562.";
RL   BMC Genomics 9:386-386(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000747; ACG79574.1; -; Genomic_DNA.
DR   RefSeq; WP_012523712.1; NC_011144.1.
DR   AlphaFoldDB; B4RA70; -.
DR   SMR; B4RA70; -.
DR   STRING; 450851.PHZ_c3165; -.
DR   EnsemblBacteria; ACG79574; ACG79574; PHZ_c3165.
DR   KEGG; pzu:PHZ_c3165; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001868; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..622
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096671"
SQ   SEQUENCE   622 AA;  65897 MW;  BD1D2EB0C1014E02 CRC64;
     MPIRRLPPEL INRIAAGEVV ERPASAVKEL VENALDAGAT KIEVQADGGG LTRILVADDG
     CGLSAEELPV AVERHATSKL NPGEDGEYDL LRIGTLGFRG EALPSIGSVA RLSIASRARK
     ADGSQAEAHA IFVEGGAVGA VSPAAFPGPH GARVEVRDLF YATPARLKFM KSERAEALAI
     TEELKRQAMA HEAVSFALDV DGRRTLRLPA EAAGPDGRLA RLSAIMGREF SDNALAIDHE
     REGVRLSGFA GLPTFNRGNA AHQYLFVNGR PVRDRLLQGA LRAAYADFLA RDRHPLAALY
     VELDPSQVDV NVHPAKAEVR FRDPGLVRGL IVGGLRHALA AAGHRASTTV SMAALGGFRP
     QSMPPPQPSA AGFSAWRQGG WTPSPAAAAA QILPGLSEVS ARAEPEALDA YAAGGMAEAA
     SPAPVFDPVD YPLGAARAQV HETYIVAQTR DGVVIVDQHA AHERLVYERM KAEMAEGGVA
     RQALLLPEVV ELDPAEAERV VARADELAAL GLVVEAFGPG AVLVREVPAL LGETDAAGLV
     RDIADDLSEN GQALALKERL EEVCGTMACH GSVRAGRRLT APEMNALLRQ MEATPHSGQC
     NHGRPTYVEL KLADIERLFG RR