ID   MUTL_PHOLL              Reviewed;         631 AA.
AC   Q7MYT9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=plu4583;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; BX571874; CAE16955.1; -; Genomic_DNA.
DR   RefSeq; WP_011148656.1; NC_005126.1.
DR   AlphaFoldDB; Q7MYT9; -.
DR   SMR; Q7MYT9; -.
DR   STRING; 243265.plu4583; -.
DR   EnsemblBacteria; CAE16955; CAE16955; plu4583.
DR   GeneID; 24169273; -.
DR   KEGG; plu:plu4583; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; YLANYQT; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; PLUM243265:PLU_RS22635-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..631
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010056"
FT   REGION          353..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   631 AA;  69690 MW;  72E801A98C8753E4 CRC64;
     MAIKILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAN RIDIEIERGG VKLIRVRDNG
     CGINHQELAL ALARHATSKI ATLDDLEAII SMGFRGEALA SISSVSRLTL TSRTEEQHEA
     WQAYAEGRDM AVTVKPAAHP VGSTVEVLDL FYNTPARRKF LRTEKTEFGH IDEVVRRIAL
     ARLDVLINLH HNGKLVRQYR PAKDESQYER RLVSICGTAF MQRALSLSWQ HDDLSIKGWV
     VDPMNTEASG DIQYCYVNGR MMRDRLINHA IRQAYQDLLR GEQQPAYVLY LGVDPHQVDV
     NVHPAKHEVR FHQARLVHDF IYQGVIAVLK QRGSGAELDI ACCEPAPAWE PENRPSAGGN
     HFSRQSNATS VAASSPKEVL SSKGNMGGSR GGENRQYHGD HYQKRQGEVY QKLMQSEPEE
     KRELFPARTA PVMAEKATSA PVQVKNSNHS FGKVLSIYSP CYALIESPLG LGLLSLPVAE
     RWLRQAQLAP TEQGLKSQPL LIPLKLSLSK EEAGALNRYS DLLGSFGIEA SVSHGKATLC
     AVSLPLRQQN LPKLIPELLG YLAQQPSASA EQVVTWLARH IGSEYETWNV AQAVQLLADV
     ERLCPQLVKS PPDGLLQLID LQAVVASLTH E