MUTL_PHOV8
ID MUTL_PHOV8 Reviewed; 622 AA.
AC A6KXH3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BVU_0422;
OS Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Phocaeicola.
OX NCBI_TaxID=435590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC 11154;
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000139; ABR38137.1; -; Genomic_DNA.
DR RefSeq; WP_005840196.1; NC_009614.1.
DR AlphaFoldDB; A6KXH3; -.
DR SMR; A6KXH3; -.
DR STRING; 435590.BVU_0422; -.
DR EnsemblBacteria; ABR38137; ABR38137; BVU_0422.
DR KEGG; bvu:BVU_0422; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_10; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR BioCyc; BVUL435590:G1G59-442-MON; -.
DR Proteomes; UP000002861; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..622
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000058137"
FT REGION 399..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 68713 MW; F1FDABB42FD8EAB9 CRC64;
MSDIIRLLPD SVANQIAAGE VIQRPASVIK ELVENAIDAG AQHVDVLVVD AGKTSIQVID
DGKGMSETDA RLSFERHATS KIREAADLFA LHTMGFRGEA LASIAAVAQV ELRTRMEGEE
LGTMLTISGS KVEGQEAVSC PKGSSFSVKN LFFNVPARRK FLKSNQTELS NILTEFERIV
LVNPEVSFTL HHNGAELFNL PALQLRQRIM GVFGKKINQE LLSLDVDTTM VRVSGFVGKP
ETARKKGARQ YFFVNGRYMR HPYFHKAIMD AYEQLVPVGE QVSYFIYFEV DPANIDVNIH
PTKTEIKFEN EQAIWQILAA AVKETLGKFN AVPSIDFDTE GMPDIPAFDA SPYTGIQPPK
TTYNPDYNPF NVSAAPPSSY SKPSKDWEQL YAGLERHASS QNFHPDENDY RAEEASPAEE
NPGLYDHVED SSVSEKSGQH YQFKGRFILT SVKSGLMIID QQRAHIRILY DKYIDQISRR
QGVSQGMLFP DIVQFPLSEV AILQEIMEDL SFLGFELTDL GGGSYAINGV PAGIEGLNPI
DLIQNMVHTA MEKGGKVKEE VQSILALTLA KAAAIVPGQV LTNEEMTGLV DGLFAVATPN
YTPDGKTVLS VINEDDLEKL FK