ID   MUTL_PORG3              Reviewed;         618 AA.
AC   B2RL29;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PGN_1555;
OS   Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM
OS   12257 / NCTC 11834 / 2561).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC   Porphyromonas.
OX   NCBI_TaxID=431947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561;
RX   PubMed=18524787; DOI=10.1093/dnares/dsn013;
RA   Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H.,
RA   Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T.,
RA   Nakayama K.;
RT   "Determination of the genome sequence of Porphyromonas gingivalis strain
RT   ATCC 33277 and genomic comparison with strain W83 revealed extensive genome
RT   rearrangements in P. gingivalis.";
RL   DNA Res. 15:215-225(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP009380; BAG34074.1; -; Genomic_DNA.
DR   RefSeq; WP_012458371.1; NZ_CP025930.1.
DR   AlphaFoldDB; B2RL29; -.
DR   SMR; B2RL29; -.
DR   STRING; 431947.PGN_1555; -.
DR   EnsemblBacteria; BAG34074; BAG34074; PGN_1555.
DR   GeneID; 29256732; -.
DR   KEGG; pgn:PGN_1555; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   OMA; AHERIMY; -.
DR   BioCyc; PGIN431947:G1G2V-1757-MON; -.
DR   Proteomes; UP000008842; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..618
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096672"
SQ   SEQUENCE   618 AA;  68740 MW;  523795B6AAFCAB9B CRC64;
     MSDVIRLLPD SIANQIAAGE VIQRPASVVK ELLENALDAG ASIIRLDVRE AGRELIRVTD
     NGKGMSQSDA RMAFERHATS KIASFQDLFS LRTMGFRGEA LASIAAVAQV ELLTRRAEDE
     LGTRLTINGS EVGEVATVTS PQGCILCVKN LFYNVPARRK FLKSNETEFR HILTEYERVA
     LVNPQVAFSI YHSGELVQDL PPSPLKKRIL DVFGKRMEKD LIPIGIKSPI TNISGFVGRP
     DGARKRGALQ YFFVNGRFMR HPYFHKAVMA AYEAIIPQGT MPNYFLYFDL EPSQIDVNIH
     PTKTEIKFSD EQAIFKLIGV VIREALSSSN AVPAIDFDRK ELIDIPAYQG PGKNVVRPPV
     DLDPSYNPFK ETGLTEPIRS SRRQSPDMGW NELFKQFEAK RDAEKMAEPP IRSEGLFAST
     DFTPSAVSAT PSTDMLCYVH RGRYLVTTLS RGLALVDFHR AHKRILYDRF MADESRRHIE
     QQQLLFPELL EFNPSDASAV KAAVDELQSV GFDLSPLGVS SYSLLAAPVQ IIDCAADVVR
     DVIHTTLEDG RSSHEQMLEL IATQIAEYQA IPCGKTPTAE EASDLLAELF ASNDSTYTPD
     GKLIVSIIEE ADIARRFE