ID   MUTL_PROA2              Reviewed;         622 AA.
AC   B4S3X8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Paes_0267;
OS   Prosthecochloris aestuarii (strain DSM 271 / SK 413).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Prosthecochloris.
OX   NCBI_TaxID=290512;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 271 / SK 413;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F., Overmann J.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001108; ACF45324.1; -; Genomic_DNA.
DR   RefSeq; WP_012504861.1; NC_011059.1.
DR   AlphaFoldDB; B4S3X8; -.
DR   SMR; B4S3X8; -.
DR   STRING; 290512.Paes_0267; -.
DR   EnsemblBacteria; ACF45324; ACF45324; Paes_0267.
DR   KEGG; paa:Paes_0267; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002725; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..622
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096673"
SQ   SEQUENCE   622 AA;  70798 MW;  75976CE83FFE50AE CRC64;
     MPRITKLPES VANKISAGEV VQRPASVVKE LIENAIDAGA GRIVLSIKDA GKQLVQIIDN
     GHGMSEPDAL MCVERFATSK ISSAEELETL GTLGFRGEAL ASISSVSHFE LKSCSEGMDA
     AFLHRYEGGE LVEKSKAAAD RGTTISVRNL FFNVPARRKF LKTNATEFKH IFETVKAQAL
     AYPEIQWQLF NDDEELFHFR SSDMHERLNF FFGEEFADSL IEIREENDFL SLYGYVGKPG
     MLKRQKNDQL FYINRRVIQN RMLSQALQQA YGELLVERQT PFALLFLGLD TRQVDINVHP
     AKLEVKFEDE RNIRNMVYPI VKRAVQLQDF APDVGIAGLL ERQMTQDAMN PENSLRKLEY
     KRAAGPSSTT DDLYRSYLSE LPPVSSPPPG SIGEQGEMFS DLLAPSRDRE LKPSVYDRSA
     LLQSDENRPD PAGSDSKIWQ LHNKYIVCQI KTGLMVIDQH VAHERVLYER AVEIMNNNVP
     NSQQLLFPQK IELKSWEYEI FQEIRDDLCR LGFNLRSFGN RTVMIEGIAQ DVRNGTEAVI
     LQNMIDEYQQ NALKLKLEKR ENLAKSYSCR NAIMSGQKLS LEEMRSLIDR LFATRMPYVC
     PHGRPVIIKI SLDQLDRMFG RK