ID   MUTL_PROMH              Reviewed;         669 AA.
AC   B4F203;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PMI3363;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/jb.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT   both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AM942759; CAR46598.1; -; Genomic_DNA.
DR   RefSeq; WP_012368716.1; NC_010554.1.
DR   AlphaFoldDB; B4F203; -.
DR   SMR; B4F203; -.
DR   STRING; 529507.PMI3363; -.
DR   EnsemblBacteria; CAR46598; CAR46598; PMI3363.
DR   GeneID; 6801721; -.
DR   KEGG; pmr:PMI3363; -.
DR   PATRIC; fig|529507.6.peg.3290; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ICKENRA; -.
DR   Proteomes; UP000008319; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..669
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096674"
FT   REGION          361..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   669 AA;  74482 MW;  884D7AA10FEF4354 CRC64;
     MAINLLPPQL ANQIAAGEVV ERPASVVKEL LENSLDAGAT TIDIDIDKGG AKLIRIRDNG
     CGISRDDLKL ALARHATSKI STLDDLEAIM SMGFRGEALA SISSVSRLTL TSRTASQEEA
     WQAYAEGRDM TVAVKPAAHP VGSTVEVLDL FYNTPARRKF LRTEKTEFGH IDEVVRRIAL
     SRFDVSINLT HNGKRVRQYR AAKETHQHHR RLSAICGNHF VDQAMQLTWE HGDLAIKGWV
     EHPLAPVQGS EIQYCYVNGR MMRDRLINHA IRQAYEGYLQ GEQQPSYVLY LTVDPHQVDV
     NVHPAKHEVR FHESRLVHDF IYQAVLSVLR QVTEDTLSLD EEDNGALTAT TFPENRQVAG
     ENVFSQPYQA PVTSSTQKKS TGAYQGSAGK GLTDTQKSPQ KTLDTRQFGE SYQRTQGMLY
     QKMMQESASD VENKEKIPLF PPRPPLNLVD VGHTTNNNET NVISVVPRSV NASAAQTDYT
     FGRVLAIYQQ KYALIESSQG LGLLALEEAD FLLKCAQLLP ENENLKPQPL LVPLKVTLSK
     DEINTFKQFQ ALISDFGIVI DISHGKATIH AVSLPLRQQN LPELLTKLLA YLATEKLCSK
     QQIGHWLAKQ LSHESGVWSQ AQAVGLLADI ERLCPQYVRQ PSKNLLQLIE LQPVVAALNN
     ERSKNANKT