ID   MUTL_PSEAE              Reviewed;         633 AA.
AC   Q9HUL8;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PA4946;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE004091; AAG08331.1; -; Genomic_DNA.
DR   PIR; F83028; F83028.
DR   RefSeq; NP_253633.1; NC_002516.2.
DR   RefSeq; WP_003106411.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; Q9HUL8; -.
DR   SMR; Q9HUL8; -.
DR   STRING; 287.DR97_2299; -.
DR   PaxDb; Q9HUL8; -.
DR   PRIDE; Q9HUL8; -.
DR   EnsemblBacteria; AAG08331; AAG08331; PA4946.
DR   GeneID; 878468; -.
DR   KEGG; pae:PA4946; -.
DR   PATRIC; fig|208964.12.peg.5179; -.
DR   PseudoCAP; PA4946; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   InParanoid; Q9HUL8; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; Q9HUL8; -.
DR   BioCyc; PAER208964:G1FZ6-5062-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..633
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177958"
FT   REGION          337..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  69748 MW;  3FD58AF0A721FE2D CRC64;
     MSEAPRIQLL SPRLANQIAA GEVVERPASV AKELLENSLD AGSRRIDVEV EQGGIKLLRV
     RDDGRGIPAD DLPLALARHA TSKIRELEDL ERVMSLGFRG EALASISSVA RLTMTSRTAD
     AGEAWQVETE GRDMQPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLRAEKT EFDHLQEVIK
     RLALARFDVA FHLRHNGKTI FALHEARDEL ARARRVGAVC GQAFLEQALP IEVERNGLHL
     WGWVGLPTFS RSQPDLQYFY VNGRMVRDKL VAHAVRQAYR DVLYNGRHPT FVLFFEVDPA
     VVDVNVHPTK HEVRFRDSRM VHDFLYGTLH RALGEVRPDD QLAPPGATSL TEPRPTGAAA
     GEFGPQGEMR LAESVLESPA ARVGWSGGSS ASGGSSGYSA YTRPEAPPSL AEAGGAYKAY
     FAPLPAGEAP AALPESAQDI PPLGYALAQL KGIYILAENA HGLVLVDMHA AHERITYERL
     KVAMASEGLR GQPLLVPESI AVSEREADCA EEHSSWFQRL GFELQRLGPE SLAIRQIPAL
     LKQAEATQLV RDVIADLLEY GTSDRIQAHL NELLGTMACH GAVRANRRLT LPEMNALLRD
     MEITERSGQC NHGRPTWTQL GLDELDKLFL RGR