ID   MUTL_PSEE4              Reviewed;         632 AA.
AC   Q1I447;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PSEEN4945;
OS   Pseudomonas entomophila (strain L48).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=384676;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L48;
RX   PubMed=16699499; DOI=10.1038/nbt1212;
RA   Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C.,
RA   Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P.,
RA   Weissenbach J., Lemaitre B., Medigue C., Boccard F.;
RT   "Complete genome sequence of the entomopathogenic and metabolically
RT   versatile soil bacterium Pseudomonas entomophila.";
RL   Nat. Biotechnol. 24:673-679(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CT573326; CAK17589.1; -; Genomic_DNA.
DR   RefSeq; WP_011535950.1; NC_008027.1.
DR   AlphaFoldDB; Q1I447; -.
DR   SMR; Q1I447; -.
DR   STRING; 384676.PSEEN4945; -.
DR   EnsemblBacteria; CAK17589; CAK17589; PSEEN4945.
DR   KEGG; pen:PSEEN4945; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000658; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..632
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010059"
FT   REGION          376..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  69791 MW;  BCDD4D6281FFD5BC CRC64;
     MSGGSRIQLL SPRLANQIAA GEVVERPASV AKELLENSLD SGARRIEVEV EQGGVKLLRV
     RDNGGGIAPD DLPLALARHA TSKIRELEDL EGVLSLGFRG EALASISSVA RLTLTSRTAD
     AGEAWQVETE GRDMTPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLKAEKT EFDHLQEVIR
     RLALARFDVG FHLRHNGKTI FSLHEATDEM ARARRVGTIC GPGFLEQALP IDVERNGLRL
     WGWVGLPTFS RSQADLQYFF VNGRAVRDKL VAHAVRQAYR DVLFNGRHPT FVLFLECDPT
     GVDVNVHPTK HEVRFREGRM VHDFLYGTLH RALADVRPED QLAAPAAASE IVRPSGQQVG
     EFGPQGEMRL ASPVLEQPQA EPRQSFTPGS GAGSGYQYQY TPRPSQPLPV AETQAVYREF
     YAPLDGTAPA SLPESQGDIP PLGYALAQLK GIYILAENAV GLVLVDMHAA HERIMYERLK
     VAMASEGLSG QPLLVPESLA LSQREADCAE EHAQWFQRLG FELQRLGPET VAIRQIPALL
     KQAEANRLVQ DVLADLMEYG TSDRIQAHLN ELLGTMACHG AVRANRRLAI PEMNALLRDM
     ENTERSGQCN HGRPTWTQMG LDDLDKLFLR GR