ID   MUTL_PSEFS              Reviewed;         633 AA.
AC   C3KDW1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PFLU_0518;
OS   Pseudomonas fluorescens (strain SBW25).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=216595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SBW25;
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AM181176; CAY46793.1; -; Genomic_DNA.
DR   AlphaFoldDB; C3KDW1; -.
DR   SMR; C3KDW1; -.
DR   STRING; 216595.PFLU_0518; -.
DR   PRIDE; C3KDW1; -.
DR   EnsemblBacteria; CAY46793; CAY46793; PFLU_0518.
DR   KEGG; pfs:PFLU_0518; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002332; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..633
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203395"
SQ   SEQUENCE   633 AA;  69617 MW;  7EB929A656006F37 CRC64;
     MNSGSRIELL SPRLANQIAA GEVVERPASV IKELLENSID SGAKRIDVDV EQGGVKLLRV
     RDDGSGISSD DLPLALARHA TSKIRDLEDL ERVMSLGFRG EALASISSVA RLTLTSRTRD
     ADQAWQVETE GRDMAPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLKAEKT EFDHLQEVIK
     RLALARFDVA FHLRHNGKTI LSLHEAHDDA ARARRVSAIC GAGFLEQALP IEIERNGLRL
     WGWVGLPTFS RSQADLQYFF VNGRAVRDKL VAHAVRQAYR DVLFNGRHPT FVLFFEVDPS
     VVDVNVHPTK HEVRFRDGRM VHDFLYGTLH RTLGDVRPDD QLSAPIVTAV VRPSGPEAGE
     FGPQGEMSLA ANLLQSPQPQ PSYTAPGSGS GAGYQYQYTP RPQSAVPVAE AQAAYREFFA
     PLPGAEPGAP VALPEGGGDI PPLGYALAQL KGIYILAENA HGLVLVDMHA AHERIMYERL
     KIAMASEGLS GQPLLVPESL AVSQREADCA EEHHSVFQKL GFELQRLGPE TLAIRQIPAL
     LKQAEANRLV ADVLADLMEY GTSDRIQAHI NELLGTMACH GAIRANRRLA LPEMNGLLRD
     MENTERSGQC NHGRPTWTQM GLDDLDKLFL RGR