ID   MUTL_PSELT              Reviewed;         549 AA.
AC   A8F560;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Tlet_0728;
OS   Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 /
OS   TMO) (Thermotoga lettingae).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Pseudothermotoga.
OX   NCBI_TaxID=416591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Foster B., Bruce D., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K.,
RA   Richardson P.;
RT   "Complete sequence of Thermotoga lettingae TMO.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000812; ABV33294.1; -; Genomic_DNA.
DR   RefSeq; WP_012002775.1; NC_009828.1.
DR   AlphaFoldDB; A8F560; -.
DR   SMR; A8F560; -.
DR   STRING; 416591.Tlet_0728; -.
DR   EnsemblBacteria; ABV33294; ABV33294; Tlet_0728.
DR   KEGG; tle:Tlet_0728; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002016; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..549
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000058150"
SQ   SEQUENCE   549 AA;  62913 MW;  F5D620F6328A6BC7 CRC64;
     MKIKRLDKSI VSRIAAGEVI TGVYSVVKEL IENSIDAGAD RIVVELINGG KSEIKVQDNG
     EGMEKDDLLV CYESHTTSKI DSFQDIYTLN SFGFRGEALY SICQISKTTI FSKTASSNLG
     HEIEVVAGHL VYEKPVQIEK GTTVIVRDLF FNVPARRKFL KSNAVEARMA VEVFERFCLS
     HPHINLILTK DQQVVYNLPA TTLVQRIKAL FPDIPMDSLK AIQSQWKDME LHGCAVSPAN
     LRRKKAIFTF VNGRFVVNQL LQSAIYSAYA DFLHQKEHPV VIVNLFLPPK DIDVNVHPQK
     IEVKFSRDEE VFRFVRDSIK SQLKIPIIHH ISRNTPAKVQ KRQVEYKSPN AKFTTTSEEM
     LIPPEDFKII GIVRKRYIIV ETEDELFIVD FHAAHERLIY NKMLSSLNQN DGTDLLIPVQ
     IELRESELAL IEKNNVLKQI GFDYEIIKNQ LIVKKIPTWL DQSDVKRFII DSIDEIKLID
     IYGLEEVMKK IIADISCKSA LRTRDRLDLS QAKYLVREIF ANKISTCPHG RPVMYSINFK
     ELDSFFERI