ID   MUTL_PSEPG              Reviewed;         632 AA.
AC   B0KKZ7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=PputGB1_4948;
OS   Pseudomonas putida (strain GB-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=76869;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Chertkov O., Brettin T.,
RA   Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., McCarthy J.K., Richardson P.;
RT   "Complete sequence of Pseudomonas putida GB-1.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000926; ABZ00833.1; -; Genomic_DNA.
DR   RefSeq; WP_012274459.1; NC_010322.1.
DR   AlphaFoldDB; B0KKZ7; -.
DR   SMR; B0KKZ7; -.
DR   STRING; 76869.PputGB1_4948; -.
DR   EnsemblBacteria; ABZ00833; ABZ00833; PputGB1_4948.
DR   KEGG; ppg:PputGB1_4948; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002157; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..632
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076705"
SQ   SEQUENCE   632 AA;  69686 MW;  7534A2A4CA22D4DD CRC64;
     MSGGSRIQLL SPRLANQIAA GEVVERPASV AKELLENSLD SGARRIDVEV EQGGVKLLKV
     RDDGSGISAD DLPLALARHA TSKIRELEDL EGVMSLGFRG EALASISSVA RLTMTSRTAS
     ASEAWQVETE GRDMTPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLKAEKT EFDHLQEVIR
     RLALARFDVG FHLRHNGKSI LSLHEAHDET ARARRVGAIC GPGFMEQALP IDVERNGLRL
     WGWVGLPTFS RSQADLQYFF VNGRAVRDKL VAHAVRQAYR DVLFNGRHPT FVLFLELEPN
     GVDVNVHPTK HEVRFREGRS VHDFLYGTLH RALADVRPED QLAAPAAVPE LARPTGQQAG
     EFGPQGEMRL ASPVLEQPRA PQQSFSNGGS GAGYQYQYTP RPSQPLPAAE AQAVYREFYK
     PLDNGAAAAT ALPESQGDIP PLGYALAQLK GIYILAENAV GLVLVDMHAA HERIMYERLK
     VAMASEGLSG QPLLVPETLA LSQREADCAE EHAQWFQRLG FELQRLGPET LAVRQIPALL
     KQAEANRLVQ DVLADLMEYG TSDRIQAHLN ELLGTMACHG AVRANRRLAI PEMNALLRDM
     ENTERSGQCN HGRPTWTQMG LDDLDKLFLR GR