ID   MUTL_PSEPK              Reviewed;         632 AA.
AC   Q88DD1;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PP_4896;
OS   Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS   / KT2440).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=160488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX   PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA   Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA   Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA   Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA   Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I.,
RA   Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A.,
RA   Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H.,
RA   Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C.,
RA   Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
RT   "Complete genome sequence and comparative analysis of the metabolically
RT   versatile Pseudomonas putida KT2440.";
RL   Environ. Microbiol. 4:799-808(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE015451; AAN70463.1; -; Genomic_DNA.
DR   RefSeq; NP_746999.1; NC_002947.4.
DR   RefSeq; WP_010955484.1; NC_002947.4.
DR   AlphaFoldDB; Q88DD1; -.
DR   SMR; Q88DD1; -.
DR   STRING; 160488.PP_4896; -.
DR   EnsemblBacteria; AAN70463; AAN70463; PP_4896.
DR   KEGG; ppu:PP_4896; -.
DR   PATRIC; fig|160488.4.peg.5231; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; Q88DD1; -.
DR   BioCyc; PPUT160488:G1G01-5238-MON; -.
DR   Proteomes; UP000000556; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..632
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177959"
SQ   SEQUENCE   632 AA;  69745 MW;  F7B93ECF5F78AD8F CRC64;
     MSGGSRIQLL SPRLANQIAA GEVVERPASV AKELLENSLD SGARRIDIEV EQGGVKLLKV
     RDDGSGISAD DLPLALARHA TSKIRELEDL EGVLSLGFRG EALASISSVA RLTLTSRTAS
     ASEAWQVETE GRDMTPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLKAEKT EFDHLQEVIR
     RLALARFDVG FHLRHNGKSI LSLHEAHDEI ARARRVGAIC GPGFMEQALP IDVERNGLRL
     WGWVGLPTFS RSQADLQYFF VNGRAVRDKL VAHAVRQAYR DVLFNGRHPT FVLFLELEPN
     GVDVNVHPTK HEVRFREGRS VHDFLYGTLH RALADVRPED QLAAPAAVPE LVRPTGQQAG
     EFGPQGEMRL ASPVLEQPRA PQQSFSNGGS GAGYQYQYTP RPSQPLPAAE AQAVYREFYK
     PLETGAAPAT ALPESQGDIP PLGYALAQLK GIYILAENAV GLVLVDMHAA HERIMYERLK
     VAMASEGLSG QPLLVPETLA LSQREADCAE EHAQWFQRLG FELQRLGPET LAIRQIPALL
     KQAEANRLVQ DVLADLMEYG TSDRIQAHLN ELLGTMACHG AVRANRRLAI PEMNALLRDM
     ENTERSGQCN HGRPTWTQMG LDDLDKLFLR GR