ID   MUTL_PSESM              Reviewed;         645 AA.
AC   Q87VJ2;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PSPTO_4944;
OS   Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=223283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-871 / DC3000;
RX   PubMed=12928499; DOI=10.1073/pnas.1731982100;
RA   Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T.,
RA   Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H., Nelson W.C.,
RA   Davidsen T.M., Zafar N., Zhou L., Liu J., Yuan Q., Khouri H.M.,
RA   Fedorova N.B., Tran B., Russell D., Berry K.J., Utterback T.R.,
RA   Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.-L., Ramos A.R.,
RA   Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P., Lazarowitz S.G.,
RA   Martin G.B., Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M.,
RA   Collmer A.;
RT   "The complete genome sequence of the Arabidopsis and tomato pathogen
RT   Pseudomonas syringae pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE016853; AAO58372.1; -; Genomic_DNA.
DR   RefSeq; NP_794677.1; NC_004578.1.
DR   RefSeq; WP_011105240.1; NC_004578.1.
DR   AlphaFoldDB; Q87VJ2; -.
DR   SMR; Q87VJ2; -.
DR   STRING; 223283.PSPTO_4944; -.
DR   EnsemblBacteria; AAO58372; AAO58372; PSPTO_4944.
DR   GeneID; 1186629; -.
DR   KEGG; pst:PSPTO_4944; -.
DR   PATRIC; fig|223283.9.peg.5058; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   PhylomeDB; Q87VJ2; -.
DR   Proteomes; UP000002515; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; ISS:JCVI.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..645
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177960"
FT   REGION          353..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          395..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   645 AA;  70972 MW;  58245DE1BF44515F CRC64;
     MTDLLLDGSE ADNAQTVLNA ARIELLSPRL ANQIAAGEVV ERPASVIKEL LENSLDSGAR
     RIDIDVEQAG IKLLKVRDDG GGISSDDLPL ALARHATSKI RDLEDLERVM SLGFRGEALA
     SISSVARLTL TSRTRDADQA WQVETEGRDM DARVQPAAHP VGTSVEVRDL FFNTPARRKF
     LKAEKTEFDH LHEVIKRMAL ARFDVAFHLR HNGKTVLSLH EAHDDTARAR RVSAICGPGF
     LEQALPIEIE RNGLHLWGWV GLPTFSRSQA DLQYFFVNGR AVRDKLVAHA VRQAYRDVLF
     NGRHPTFVLF FEVDPAAVDV NVHPTKHEVR FRDGRMVHDF LYGTLHRALG DVRPENQLGG
     SVPAAAEPRP TGPDAGEFGP QGEMRLANNV LEQPQGEPFA RPAGGGSGSG YQYSPRPTTG
     VPVAEAQSAY REFFAPLPGT TPSALPESPS DIPPLGYALA QLKGIYILAE NAHGLVLVDM
     HAAHERIMYE RLKIAMANEG LSGQPLLVPE SIAVSQREAD CAEEHITTFQ RLGFELQRLG
     PETLAIRQIP ALLKQAEANR LVSDVLADLM EYGTSDRVQA HMNELLGTMA CHGAIRANRR
     LAIPEMNGLL RDMENTERSG QCNHGRPTWT QMGLSDLDKL FLRGQ