ID   MUTL_PSET1              Reviewed;         618 AA.
AC   Q3IDU0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PSHAa0269;
OS   Pseudoalteromonas translucida (strain TAC 125).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=326442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAC 125;
RX   PubMed=16169927; DOI=10.1101/gr.4126905;
RA   Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N.,
RA   Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C.,
RA   Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C., Rouy Z.,
RA   Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A.;
RT   "Coping with cold: the genome of the versatile marine Antarctica bacterium
RT   Pseudoalteromonas haloplanktis TAC125.";
RL   Genome Res. 15:1325-1335(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CR954246; CAI85368.1; -; Genomic_DNA.
DR   RefSeq; WP_011326982.1; NC_007481.1.
DR   AlphaFoldDB; Q3IDU0; -.
DR   SMR; Q3IDU0; -.
DR   STRING; 326442.PSHAa0269; -.
DR   EnsemblBacteria; CAI85368; CAI85368; PSHAa0269.
DR   KEGG; pha:PSHAa0269; -.
DR   PATRIC; fig|326442.8.peg.256; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ITLTHNE; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; PHAL326442:PSHA_RS01335-MON; -.
DR   Proteomes; UP000006843; Chromosome I.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..618
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000071508"
FT   REGION          348..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..387
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   618 AA;  68414 MW;  48F687DB922A6DA7 CRC64;
     MSIEILPARL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIQIDIERGG HKLIRIRDNG
     AGIAQDELTL ALSRHATSKL KSLDDLENIC SLGFRGEALA SISSVSRLTL SSKTKHQEAA
     WQAFAQGRDM AVQVKPVAHP DGTTIEVKDL FFNTPARRKF LRTEKTEFSH IDELIKRIAL
     SRFDVSITLT HNEKVVRQYR AKTDPSQAIA RVAQVAGKAF AEQGLHIQSG EGGLQLHGWV
     LPVGSANTVQ YTYVNNRMMR DKLILHAIRQ AFEEVSGAQE LPGFVIYIDI DPRQVDVNVH
     PAKHEVRFHQ GRLVHDFILQ AIKQVVVPLQ GEFTNEPLNN LADTAFSQTD TARSPTGNFE
     SGEVFDYPKS QLQPSHSVSS GGASLGSRSA GGSGGAYRAT PSTNHHDINA FYQGVSEQHA
     AHFDQGAHVS VGVNQSHAVE QAVALKTVAI ISINEGVCVF SSEQQLYCSH FKYALVDDWH
     EQIKEQGSLE GKALLLPVRV NLSKQDCELI AAQQSWFTLL GFELIIEKQF VMVKKLPACL
     YLLDVTSAVE SLLEACKAPL ENIESWLAWQ MQHTPARFYS SNIFLAQQAR MQNNPQTIER
     LRVKAVKIDI EHYLMQLD