ID   MUTL_PSEU5              Reviewed;         625 AA.
AC   A4VQP2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PST_3670;
OS   Pseudomonas stutzeri (strain A1501).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=379731;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A1501;
RX   PubMed=18495935; DOI=10.1073/pnas.0801093105;
RA   Yan Y., Yang J., Dou Y., Chen M., Ping S., Peng J., Lu W., Zhang W.,
RA   Yao Z., Li H., Liu W., He S., Geng L., Zhang X., Yang F., Yu H., Zhan Y.,
RA   Li D., Lin Z., Wang Y., Elmerich C., Lin M., Jin Q.;
RT   "Nitrogen fixation island and rhizosphere competence traits in the genome
RT   of root-associated Pseudomonas stutzeri A1501.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:7564-7569(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000304; ABP81293.1; -; Genomic_DNA.
DR   RefSeq; WP_011914685.1; NC_009434.1.
DR   AlphaFoldDB; A4VQP2; -.
DR   SMR; A4VQP2; -.
DR   STRING; 379731.PST_3670; -.
DR   EnsemblBacteria; ABP81293; ABP81293; PST_3670.
DR   KEGG; psa:PST_3670; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000233; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..625
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000058148"
SQ   SEQUENCE   625 AA;  69046 MW;  F3FF39148BA8F7CF CRC64;
     MTQAPRIQLL SPRLANQIAA GEVVERPASV IKELLENSLD SGAGRIEVDV EQGGVKLLRV
     RDDGCGIPPD DLPLALARHA TSKIRDLEDL ERVMSLGFRG EALASISSVS RLTLTSRTAD
     ASEAWQVETE GREMEARVQP AAHPVGTSVE VRDLFFNTPA RRKFLRTEKT EFDHLQEVIK
     RLALARFDVA FHLRHNGKGV LALHQANDDS ARARRVAAVC GPAFLEQALP IEIERNGLRL
     WGWVGLPTFS RSQADLQYFY VNGRMVRDKL VAHAVRQAYR DVLFNGRHPT FVLFLDVDPA
     VVDVNVHPTK HEVRFRDSRM VHDFLYGTLH RALGDVRPED QLAAPASVAP MTQVSGLAAG
     EFAGQNEMSL SASVLERPQG ETPAWRGAGA GYQAPRPASA GYTAEAQGAY REFFTPLPES
     AAAPLPASQD DVPPLGYALA QLKGVYILAE NAQGMVLVDM HAAHERITYE RLKTAMASEG
     LRGQPLLVPE SIALSQREAD CAEEHAQWFQ MLGFELQRLG PETLAIRQIP SLLKQAEATQ
     LVRDVLADLL EYGTSDRIQA HLNELLATMA CHGAVRANRR LTLPEMNALL RDMEHTERSG
     QCNHGRPTWT QLGMDDLDKL FLRGR