ID   MUTL_PSYIN              Reviewed;         628 AA.
AC   A1SZL2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Ping_3240;
OS   Psychromonas ingrahamii (strain 37).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Psychromonadaceae; Psychromonas.
OX   NCBI_TaxID=357804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=37;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Staley J.,
RA   Richardson P.;
RT   "Complete sequence of Psychromonas ingrahamii 37.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000510; ABM04927.1; -; Genomic_DNA.
DR   RefSeq; WP_011771479.1; NC_008709.1.
DR   AlphaFoldDB; A1SZL2; -.
DR   SMR; A1SZL2; -.
DR   STRING; 357804.Ping_3240; -.
DR   EnsemblBacteria; ABM04927; ABM04927; Ping_3240.
DR   KEGG; pin:Ping_3240; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000639; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..628
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000071509"
FT   REGION          333..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..390
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  70468 MW;  B2763327C46AD23D CRC64;
     MPIQILAARL ANQIAAGEVV ERPASVVKEL IENSLDAGAT KIEIDIEKGG AKCIRVKDNG
     AGVCQEQLTL ALSRHATSKI SHLDDLEAIV SLGFRGEALA SVSSVSRLTF TSKPADQEQA
     WQAIAEGRDM QVTIQPAAHP QGTTVEVLDL FFNTPARRRF LKTEKTEFQH IDELIRRIAL
     SRFEITFVLK HNHKIVHQYR ATQTQSQQEK RLASICSESF VSSALYFQNS DNALKISGWV
     SDKLSARSSN DVQYCYINGR VIRDKLINHA IKQVYAYSLP QGKFPAYVIY IECDPDQVDV
     NVHPSKHEVR FHQARWVHDF IVSTLTVTLN ESPLSASEPQ SQPKPSEHAY LPANRGEEKT
     DSQYEPKEKN KSAGRVNEQT AAPSSGYAKR ETNPQLDQAK MAAYCDFVAE AHLPFSADEQ
     QSSTLSDLTF ATVVCLIDRQ YLLIKLNAKQ QLLNIDSPFL VLSLENVDLM IKQMELFAAW
     SDGEVIAQPL LLPVRVELDA LLLKTSEDFN ELFMRLGFVF KIQGSKLIIS KVPALLRQAP
     VAKIIPELLT FLSQTDNNMD AQQVNLFCVF LVNTLKQQQA ENINWTEQSA KALFDLLLSL
     FSEKLSDWQK QLFRVPDLSL LVQGFSHE